Abstract: Objective To investigate the application of paravertebral block anesthesia combined with general anesthesia in patients with hepatic hemangioma resection. Methods 123 patients with hepatic hemangioma were admitted to our hospital between June 2014 and December 2016,and were divided into observation group （n=62） and control group（n=61） by digital parity method, receiving general and paravertebral block anesthesia,or general anesthesia alone when resection of hepatic hemangioma underwent. The degree of pain was determined by visual analogue pain score （VAS）,and serum levels of tumor necrosis factor alpha （TNF-α） and soluble triggering receptor expressed on myeloid cell-1（sTREM-1） were measured by enzyme-linked immunosorbent assay. Results At 3 h,24 h and 48 h post-operation,the VAS scores in the observation group were（3.6±1.1）,（3.1 ± 0.9） and （2.9±0.7）,respectively,significantly lower than [（4.5±1.5）,（3.8±1.2） and （3.5±3.5）,P<0.05] in the control group; at 24 h and 72 h postoperation,serum TNF-α levels in the observation group were（135.1±21.8）pg/ml and （99.3±18.2） pg/ml,much lower than【（230.5±32.1） pg/ml and （183.7±22.7）pg/ml,P<0.05】 in the control,and serum sTREM-1 levels were（215.9±29.6）pg/ml and （168.5±25.3） pg/ml,also much lower than 【（295.4±41.6）pg/ml and（241.8±27.4）pg/ml,P<0.05】 in the control group;the extubation time after surgery in the observation group was （5.3±1.9） h,significantly shorter than [（6.3±2.1） h,P<0.05],the duration of ICU stay was （25.5±8.6） h,significantly shorter than [（31.6±9.8） h,P<0.05],the hospitalization stay was （9.4±2.1） d,much shorter than [（10.6±2.4） d,P<0.05],and the dosage of sufentanil administration was（1.5±0.3） mg,significantly lower than [（2.5±0.4） mg,P<0.05] in the control;the total incidence of pain related adverse events in the observation group was 16.2,significantly lower than 34.4% in the control（P<0.05）. Conclusion The paraspinal block anesthesia at the basis of general anesthesia might reduce the postoperative pain, get down blood inflammatory factor levels,and decrease pain related adverse events in patients with hepatic hemangioma resection.

Key words: Hepatic hemangioma, Surgical resection, Paravertebral block anesthesia, Postoperative pain, Cytokines