Abstract: Objective To investigate the efficacy of polyene phosphatidylcholine（PPC） in patients with moderate -to-severe nonalcoholic fatty liver disease （NAFLD）. Methods A total of 90 patients with moderate -to-severe NAFLD were recruited in our hospital between January 2013 and December 2016,and were randomly divided into three groups by computer-generated randomized numbers. The patients in control received routine treatment, and those in observation group one received PPC orally,and in observation group two received PPC intravenously for eight weeks. Results At the end of the observation,the ultrasound scores in observation group one and two were （3.2±0.7） and（3.3±0.6）,much lower than （4.5±0.6） in the control,and the liver/spleen CT ratios were（0.9±0.2） and （0.9±0.1）,much higher than （0.7±0.2） in the control （P<0.05）;serum levels of total cholesterol （TC）,triglyceride（TG） and low density lipoprotein （LDL-C） in observation group one were（4.8±0.6）mmol/L,（2.0±0.2）mmol/L and（3.0±0.2）mmol/L,and in observation group two were （4.7±0.6）mmol/L,（1.9±0.3）mmol/L and （2.9±0.3）mmol/L,much lower than（5.1±0.5）mmol/L,（2.2±0.2）mmol/L and（3.3±0.3） mmol/L,while high density lipoprotein （HDL-C） were （1.4±0.4）mmol/L and （1.4±0.3）mmol/L,respectively,much higher than （1.3±0.3）mmol/L in the control（P<0.05）;serum tumor necrosis factor-α（TNF-α）,monocyte chemotactic protein-1（MCP-1） and nuclear factor-κB （NF-κB） levels in observation group one were （10.3±2.6）ng/ml,（4.6±0.7） ng/mL and （9.4±1.1）ng/ml,and in group two were （9.8±2.3）ng/mL,（4.4±0.6）ng/ml and （9.6±1.4）ng/ml,much lower than（22.5±3.6）ng/ml,（9.3±1.1）ng/ml and（16.3±2.5）ng/ml in the control,while serum heme oxygenase-1 （HO-1）,glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） levels were much higher than those in the control（P<0.05）. Conclusion There is no significant difference in the efficacy and safety of PPC orally and intravenously in the treatment of patients with NAFLD. The therapy might promote blood lipid metabolism, and the possible mechanism might be related to the inhibition of inflammatory reaction and oxidative stress response.

Key words: Non-alcoholic fatty liver, Polyene phosphatidylcholine, Inflammatory cytokines, Oxidative stress, Therapy