Abstract: Objective To analyze the risk factors for gastric bleeding in patients with hepatitis B-induced liver cirrhosis and portal hypertensive gastropathy （PHG）. Methods 128 hepatitis B liver cirrhosis patients with PHG were retrospectively analyzed between January 2014 and December 2015. The incidence of gastric bleeding in each condition was compared. The multivariate Logistic regression analysis was performed to get independent risk factors when any significant statistical results were found. Results In 128 eligible patients with hepatitis B cirrhosis and PHG,49 patients（38.3%） had acute gastric bleeding;the prevalence of acute gastric bleeding in patients with and without underlying gastric diseases were 60.0% vs. 30.1%（P<0.05）,with and without Helicobacter pylori infection were 54.8% vs. 33.0% （P<0.05）,with and without ascites were 46.3% vs. 23.9% （P<0.05）,with Child-Pugh class C,class B and class A were 58.3%,41.5% and 15.4%（P<0.05）,with severe, moderate and mild esophageal varices（EV） were 51.8%,41.9% and 6.9%（P<0.05）,with and without regular antiviral therapy were 55.6% vs. 31.5% （P<0.05）,with portal vein diameter wider than and less than 14 mm were 48.3% vs. 30.0% （P<0.05）,with splenic vein diameter wider than and less than 9 mm were 48.4% vs. 28.8% （P<0.05）;Multivariate analysis showed that underlying gastric diseases,poor Child-Pugh classification, severe EV degree and wider portal vein diameter were the independent risk factors for acute gastric bleeding in patients with hepatitis B cirrhosis and PHG. Conclusion The patients with hepatitis B cirrhosis and PHG have a risk of gastrointestinal bleeding,and should be supervised for early prophylaxis and treatment.

Key words: Liver cirrhosis, Portal hypertensive gastropathy, Gastrointestinal bleeding, Risk factors