Abstract: Objective To investigate the prevalence of renal function insufficiency in patients with hepatitis B（HB） related cirrhosis and to explore the risk factors for renal insufficiency. Methods 289 patients with HB-related cirrhosis were recruited in our hospital between Jan.2015 and Dec. 2015. The renal function was evaluated by serum creatinine（sCr）,endogenous creatinine clearance （cCr） or the estimated glomerular filtration rate （eGFR） levels. The risk factors affecting renal function were screened by applying Logistic regression analysis. Results A total of 289 hospitalized patients with HB-related cirrhosis were enrolled,including 95 Child-Pugh class A,122 Child-Pugh class B and 72 Child-Pugh class C. The incidence of renal insufficiency assessed by eGFR as <90 ml·min^-1·1.73 m² was 20.76%,significantly higher than 3.81% assessed by sCr or 13.15% by cCr（P<0.05）;the incidence of renal insufficiency in Child-Pugh class C was 29.17%,significantly higher than 13.68% in Child-Pugh class A or 21.31% in Child-Pugh class B（P<0.05）;Univariate Logistic regression analysis showed that age,Child-Pugh classification,hyperuricemia and hyponatremia were related to the occurrence of renal insufficiency,while multivariate Logistic regression analysis identified age,hyperuricemia and hyponatremia as independent risk factors for renal insufficiency,in patients with hepatitis B-related cirrhosis（P<0.05）. Conclusion eGFR assessment might reflect the existence of renal insufficiency earlier than by sCr or cCr assessment. Development of renal insufficiency in patients with hepatitis B-related cirrhosis is associated with Child-Pugh scores,while age,hyperuricemia and hyponatremia are independent risk factors for the occurrence of renal injuries.

Key words: Liver cirrhosis, Hepatitis B, Estimated glomerular filtration rate, Renal insufficiency, Risk factors