Abstract: Objective To study the therapeutic effects of transcatheter arterial chemoembolization combined with lienalis infusion indirectly to portal vein in treating patients with primary liver cancer. Methods 30 patients with PLC underwent transcatheter arterial chemoembolization treatment,while 40 underwent transcatheter arterial chemoembolization combined with lienalis infusion to portal vein. The serum levels of TNF-α,IL-2,sIL-2R and VEGF were assessed by ELISA. Results The serum levels of TNF-α,sIL-2R as well as the VEGF levels in the two groups decreased（P<0.01）,while IL-2 increased（P<0.01）after treatment;The 1,2 and 3 year survival rates of patients with transcatheter arterial chemoembolization combined with lienalis infusion to portal vein were 72.5%,55% and 25%,higher than that of single TACE therapy group（60%,30% and 6.7%,respectively,P<0.05）. Conclusion Transcatheter arterial chemoembolization combined with lienalis infusion in treating patients with primary liver cancer can improve the immune function and enhance the curative effect.

Key words: Hepatoma, Transcatheter arterial chemoembolization, TNF-α, IL-2, sIL-2R, VEGF