生长抑素联合奥曲肽治疗肝硬化并发上消化道出血患者疗效及其对凝血功能指标的影响再观察

doi:10.3969/j.issn.1672-5069.2020.05.023

Abstract

Abstract: Objective The aim of this study was to analyze the efficacy and impact on blood coagulation functions of somatostatin and octreotide combination in the treatment of cirrhotic patients with upper gastrointestinal hemorrhage. Methods 70 cirrhotic patients with upper gastrointestinal hemorrhage were admitted to our hospital between July 2017 and May 2019, and they were randomly divided into control and observation group, with 35 cases in each. The patients in the control group were treated by intravenous infusion of octreotide and those in the observation group were treated by intravenous infusion of somatostatin and octreotide combination for 3 to 7 days. All patients were followed-up for two weeks. Blood prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) were monitored. Results At the end of two week treatment, blood albumin level in the combination group was (33.5±3.1)g/L, significantly higher were than 【(31.8±2.3)g/L, P<0.05】, while serum bilirubin and blood ammonia levels (30.9±10.2)μmol/L and (32.5±11.8)μmol/L, much lower than 【(41.4±14.3)μmol/L and (45.2±14.6)μmol/L, respectively, P<0.05】 in the control; the PT was (12.4±1.9) s, significantly shorter than 【(14.1±2.3) s, P＜0.05】, the TT was (18.2±2.1) s, significantly shorter than 【(20.4±2.5) s, P＜0.05】, the APTT was (34.5±4.8) s, much shorter than 【(37.3±5.2) s, P＜0.05】, and the FIB level was (2.4±0.6) g/L, significantly higher than 【(2.1±0.5) g/L, P＜0.05】 in the control; the hemostasis time and hospital stay in the combination group were (20.7±3.1)h and (8.5±2.3)d, significantly shorter than 【(24.6±3.9)h and (10.3±2.5)d, P＜0.05】 in the control, and the incidence of 72 hour re-bleeding was 5.7%, significantly lower than 20.0%(P＜0.05) in the control. Conclusion The combination of somatostatin and octreotide in the treatment of cirrhotic patients with upper gastrointestinal hemorrhage greatly reduce the amount of blood transfusion, shorten the hemostasis time and hospital stay, which might be related to the correction of abnormal coagulation function.

Key words: Liver cirrhosis, Upper gastrointestinal hemorrhage, Somatostatin, Octreotide, Coagulation function, Therapy

Yang Xi, Song Dongmei, Hua Min.. Efficacy and impact on blood coagulation functions of somatostatin and octreotide combination in the treatment of cirrhotic patients with upper gastrointestinal hemorrhage[J]. Journal of Practical Hepatology, 2020, 23(5): 695-698.

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Efficacy and impact on blood coagulation functions of somatostatin and octreotide combination in the treatment of cirrhotic patients with upper gastrointestinal hemorrhage

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