Abstract: Objective The aim of this study was to investigate the efficacy of adenosylmethionine and blue light treatment in neonatal jaundice. Methods 196 children with neonatal jaundice were treated in our hospital between May 2017 and May 2019, and they were divided randomly into control (n=98) and observation group (n=98). The neonates in the control group were given blue light illumination (BLI), and those in the observation group were treated with adenosylmethionine succinate enteric-coated tablets and BLI combination for one week. All the children were followed-up for one week. Serum transferrin (TRF) and C-reactive protein (CRP), creatine kinase (CK) , creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) levels were detected. Results At the end of one week follow-up, in the combination group, serum alanine aminotransferase (ALT) level was (37.1±12.6) U/L, significantly lower than in the control group , serum aspartate aminotransferase (AST) level was(36.2±11.6)U/L, not significantly different as compared to 【(45.1±13.7)U/L, P>0.05】 in the control, while serum bilirubin level was (31.2±3.7) μmol/L, significantly lower than 【(62.5±7.1)μmol/L, P<0.05】 in the control; serum CRP level was (8.6±1.3)U/L, much lower than 【(11.3±1.9)U/L, P<0.05】, serum CK level was (177.7±61.7)U/L, significantly lower than 【(209.6±72.1)U/L, P<0.05】, serum CK-MB level was (3.8±0.4)U/L, significantly lower than 【(5.4±0.9)U/L, P<0.05】, serum LDH level was (350.5±103.1)U/L, significantly lower than 【(392.6±120.2) U/L, P<0.05】, while serum TRF level was (1964.8±91.6)U/L, significantly higher than 【(1687.9±88.2)U/L, P<0.05】 in the control; the incidence of adverse reactions in the observation group was 11.2%, not significantly different as compared to 14.3% (P<0.05) in the control group. Conclusion The administration of adenosine methionine might assist subside jaundice in neonates at the base of BLI treatment, which needs further investigation.

Key words: Neonatal jaundice, Adenosylmethionine succinate enteric-coated tablets, Blue light , Myocardial enzymes, Therapy