茵栀黄联合腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症患者疗效观察及其对母婴结局的影响

doi:10.3969/j.issn.1672-5069.2020.05.017

Abstract

Abstract: Objective The aim of this study was to analyze the short-term efficacy of yinzhihuang, a herbal medicine, and adenosine methionine combination in the treatment of patients with intrahepatic cholestasis of pregnancy (ICP) . Methods 74 patients with ICP were admitted to our hospital between July 2016 and May 2019, and were randomly divided into control (n=37) and observation group (n=37) . The patients in the control group were treated with UDCA and adenosine methionine, and those in the observation group were treated with yinzhihuang at the base of UDCA and adenosine methionine. The regimen continued about four weeks until delivery. Serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), IL-18 and transforming growth factor-β (TGF) were detected by ELISA, and itch score was assessed by Ai Ying modified criteria and sleeping was by Pittsburgh sleep quality index (PSQI). Results At about four week treatment before delivery, serum alanine aminotransferase level was (39.7±6.2) U/L, significantly lower than [(58.5±7.4) U/L, P<0.05) , serum aspertate aminotransferase level was (42.9±6.6) U/L, significantly lower than [(63.1±8.3) U/L, P<0.05), total serum bilirubin level was (15.4±4.8) μmol/L, significantly lower than [(19.7±6.5) μmol/L, P<0.05), serum total bile acid level was (13.2±3.7) μmol/L, significantly lower than , the itch score was (1.2±0.3) points, significantly lower than , and the PSQI score was (8.9±2.5) points, significantly lower than in the control; serum TNF-α levels was (29.4±5.3) ng/L, significantly lower than [(38.2±6.1) ng/L, P<0.05), serum IL-18 level was (38.2±6.7) ng/L, significantly lower than [(45.6±7.8) ng/L, P<0.05), and serum TGF-β levels was (4.2±1.5) ng/L, significantly lower than in the control; the incidence of adverse pregnancy outcomes and neonatal adverse outcomes in the two groups were not significantly different (32.5% vs. 35.5%, and 11.7% vs. 12.9%,respectively, P>0.05). Conclusion The application of Yinzhihuang conpound and adenosine methionine combination in the treatment of patients with ICP have a good efficacy, which might significantly improve liver function tests, reduce serum cytokine levels, relieve pruritus symptoms and improve sleep.

Key words: Intrahepatic cholestasis of pregnancy, Yinzhihuang, herbal medicine, Adenosine methionine, Therapy, Prognosis

Xing Xiaoyan,Huang Liangmiao, Fu Aixian,et al.. Short-term observation of yinzhihuang and adenosine methionine in treatment of patients withintrahepatic cholestasis of pregnancy[J]. Journal of Practical Hepatology, 2020, 23(5): 670-673.

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Short-term observation of yinzhihuang and adenosine methionine in treatment of patients withintrahepatic cholestasis of pregnancy

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