多烯磷脂酰胆碱联合双环醇治疗胃癌化疗导致的药物性肝损伤患者疗效及其对血清细胞因子和氧化应激指标水平的影响

doi:10.3969/j.issn.1672-5069.2020.05.016

Abstract

Abstract: Objective The aim of this study was o investigate the short-term efficacy of polyene phosphatidylcholine and bicyclol combination in treatment of gastric cancer patients with chemotherapy-induced liver injury. Methods 78 patients with gastric cancer were admitted to our hospital between May 2017 and May 2019, and all of them underwent radical resection of gastric cancer and received chemotherapy. During the treatment, the drug-induced liver injuries (DILI) was found in 40 patients. Out of them, 19 received with polyene phosphatidylcholine and 21 with polyene phosphatidylcholine and bicyclol combination therapy for liver interleukin-6 (IL-6), malondialdehyde (MDA) function protection for 4 weeks. Serum tumor necrosis factor (TNF-α), and superoxide dismutase (SOD) levels were assayed, respectively. Results At the end of four week treatment, serum alanine aminotransferase level in the combination group was (33.5±7.9)U/L, significantly lower than 【(42.4±8.8)U/L, P<0.05】, serum aspartate aminotransferase level was (34.4±5.7)U/L, much lower than 【(39.4±6.2)U/L, P<0.05】, serum alkaline phosphatase level was (60.6±14.2)U/L, significantly lower than 【(75.3±16.6)U/L, P<0.05】, while Karnofsky performance status score was (64.1±17.2), much higher than 【(48.3±14.5), P<0.05】 in the control; the rate of liver function test normalization in the combination group was 81.0%, significantly higher than 63.2%(P<0.05) in the control; serum TNF-α level in the combination group was (15.2±2.1)mg/L, significantly lower than 【(21.4±3.6)mg/L, P<0.05】, serum IL-6 level was (28.1±4.5)pg/mL, significantly lower than 【(46.2±5.9)pg/mL, P<0.05】, serum MDA level was (5.1±0.8)nmol/mL, significantly lower than 【(5.9±0.7)nmol/mL, P<0.05】, while serum SOD level was (2.3±0.5)U/mL, much higher than 【(1.8±0.4)U/mL, P<0.05】 in the control. Conclusion The application of bicyclol combined with polyene phosphatidylcholine in treatment of patients with DILI could improve liver function recovery, which might be related to the inhibition of oxidative stress and cytokine burst.

Key words: Drug-indeced liver injury, Bicyclol, Polyene phosphatidylcholine, Gastric cancer, Tumor necrosis factor, Interleukin-6, Therapy

Wu Jie, Xie Lixiang , Xiu jin .. Short-term efficacy of polyene phosphatidylcholine and bicyclol combination in treatment of gastric cancer patients with chemotherapy-induced liver injury[J]. Journal of Practical Hepatology, 2020, 23(5): 666-669.

References

[1] Sato N, Nakayama A, Takai Y, et al. A case of her2-positive unresectable gastric cancer with multiple lymph node and livermetastases controlled effectively by combination chemotherapy with capecitabine, oxaliplatin, and trastuzumab. Gan To Kagaku Ryoho, 2017, 44(12): 1266-1268.
[2] Miwa T, Kanda M, Umeda S, et al. Homeobox c10 influences on the malignant phenotype of gastric cancer cell lines and its elevated expression positively correlates with recurrence and poor survival. Ann Surg Oncol, 2019, 26(5): 1535-1543.
[3] Matsushita K, Takeno A, Tamura S, et al. A case of granulocyte-colony stimulating factor-producing gastric cancer successfully treated with trastuzumab. Gan To Kagaku Ryoho, 2015, 42(12): 1968-1970.
[4] 周志菁, 黄永东. 多烯磷脂酰胆碱治疗中重度非酒精性脂肪性肝病患者疗效初步研究. 实用肝脏病杂志, 2018, 21(5): 733-736.
[5] Naiqiong W, Liansheng W, Zhanying H, et al. Med Sci Monit, 2017, 23(4): 5760-5766.
[6] 曹惠华, 束平, 唐兆庆, 等. 美国癌症联合会第7版与第8版胃癌TNM分期系统的差异及其对预后评估的比较(附1383例报告). 中华消化外科杂志, 2018, 17(6): 605-611.
[7] 于乐成, 茅益民, 陈成伟. 药物性肝损伤诊治指南. 实用肝脏病杂志, 2017, 20(2): 257-274.
[8] Haghazali M, Molaei M, Mashayekhi R, et al. Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with helicobacter pylori. Indian J Pathol Microbiol, 2016, 54(1): 103-106.
[9] Stine JG, Lewis JH. Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Rev Gastroenterol Hepatol, 2016, 10(4): 517-536.
[10] Krause L, Nones K, Loffler KA, et al. Identification of the cimp-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma. Carcinogenesis, 2016, 37(4): 356-365.
[11] Nishimura S, Saeki H, Ikegami T, et al. Living donor liver transplantation followed by total gastrectomy--a two-stage planed operative strategy for early gastric cancer concomitant with decompensated liver cirrhosis. Anticancer Res, 2014, 34(8): 4307-4310.
[12] Chalasani NP, Hayashi PH, Bonkovsky HL, et al. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol, 2014, 109(7): 950-966.
[13] Akamaru Y, Wada N, Hirao T, et al. A case of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis achieving recurrence-free survival for five years by gastrectomy, hepatectomy, and adjuvant chemotherapy. Gan To Kagaku Ryoho, 2017, 44(12): 1775-1777.
[14] Ma J, Sawai H, Matsuo Y, et al. Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines. J Surg Res, 2018, 148(2): 197-204.
[15] Yanagihara K, Takigahira M, Kubo T, et al. Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer. Ther Deliv, 2014, 5(2): 129-138.
[16] 郝海波, 王先化, 赵善良, 等. 双环醇治疗抗结核药致肝损害疗效的Meta分析. 中华疾病控制杂志, 2018, 22(4): 390-395.
[17] Attar M, Mansoori M, Shahbazi M, et al. Interleukin-6 genetic variation and susceptibility to gastric cancer in an iranian population. Asian Pac J Cancer Prev, 2017, 18(11): 3025-3029.
[18] Qiu G, Wang Q, Zhu J, et al. Palladium-catalyzed three-component reaction of propargyl carbonates, isocyanides, and alcohols or water: switchable synthesis of pyrroles and its bicyclic analogues. Org Lett, 2017, 19(1): 270-273.
[19] Sun B, Lapetino SR, Diffalha SA, et al. Microvascular injury in persistent gastric ulcers after yttrium-90 microsphere radioembolization for liver malignancies. Hum Pathol, 2016, 50(1): 11-14.
[20] Shimada H, Noie T, Ohashi M, et al. Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the task force of the Japanese gastric cancer association. Gastric Cancer, 2014, 17(1): 26-33.

Short-term efficacy of polyene phosphatidylcholine and bicyclol combination in treatment of gastric cancer patients with chemotherapy-induced liver injury

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