Abstract: Objective The aim of this study was to analyse the CT liver perfusion imaging parameters in patients with schistosomiasis-induced liver cirrhosis. Methods 40 patients with schistosomiasis-induced liver cirrhosis (Child A in 12, B in 16 and C in 12) and 40 healthy persons were recruited in our hospital between May 2016 and October 2018, and all of them underwent liver perfusion of spiral CT scanning. The blood volume (BV), blood flow (BF) , mean transit time (MTT), hepatic artery fraction (HAF) and hepatic artery perfusion (HAP) were obtained by CT Perfusion 4D software. Results The BV, BF, MTT, HAF and HAP in healthy persons were (45.7±8.4)mL/100g, (212.6±43.3)mL/min·100g, (13.5±2.3) s, (0.2±0.0) and (16.3±8.3)mL/min·100g, while in patients with Child class A were (41.0±15.3)mL/100g, (185.6±38.4)mL/min·100g,(15.2±1.2) s, (0.2±0.0) and (20.5±8.0)mL/min·100g, in patients with Child class B were (38.5±20.6)mL/100g, (126.6±90.5)mL/min·100g,(19.4±11.4) s,(0.3±0.0) and (26.7±2.0)mL/min·100g, and in with Child class C were (23.3±8.7)mL/100g, (129.4±46.6)mL/min·100g, (27.5±2.7) s, (0.4±0.1) and (35.2±12.6)mL/min·100g, respectively, showing significantly different among the four groups (P<0.05). Conclusion CT liver perfusion imaging parameters might be used to evaluate the liver functions and cirrhosis in schistosomiasis-induced liver cirrhosis, which is worthy of further investigation.

Key words: Liver cirrhosis, Schistosomiasis, Child-Pugh class, Multi-slice spiral CT scan, Perfusion imaging, Blood parameters