Abstract: Objective To investigate the clinical feature and prognosis of low birth weight infants with cholestasis. Methods 162 low birth weight infants with cholestasis between June 2014 and June 2015 in our hospital were retrospectively analyzed，and 143 infants had with parenteral nutrition associated cholestasis （PNAC） and 19 were not. Multivariate Logistic regression analysis was applied for risk factors of PNAC occurrence. Results The body weight at birth in PNAC and non-PNAC infants were 【（1237.2±173.3） g vs.（1377.3±177.9） g，respectively，P<0.05】，the cumulative amount of lipid emulsion in PNAC infants was（35.7±10.5）g·kg^-1，much higher than 【（27.3±12.3）g·kg^-1，P<0.05】，amino acids was （36.6±11.2）g·kg^-1，much higher than 【（28.2±11.7）g·kg^-1，P<0.05】，the duration for PN was（30.7±14.1）d，much longer than 【（22.1±6.2）d，P<0.05】 and hospitalization stay was （51.2±11.2）d，much longer than【（37.4±10.5）d，P<0.05】 in the non-PNAC infants；the incidences of anemia and infection in children with PNAC were 85.3 % and 73.4 %，significantly higher than 68.4 % and 42.1 % in non-PNAC group（P<0.05）；Multivariate Logistic regression analysis showed that the low weight at birth，the cumulative amount of fat and amino acids，and the duration of PN were the risk factors for the occurrence of PNAC. Conclusions There are many factors influencing the occurrence of cholestasis in low birth weight infants，and we should give them an appropriate feeding，preventing and managing complications in time，and improving them recovery.

Key words: Cholestasis, Low birth weight infants, Clinical feature, Parenteral nutrition