Abstract: Objective To investigate the clinical effects of Antike capsule given after ultrasound-guided radiofrequency ablation under guidance of real time virtual sonography navigation system in the treatment of patients with hepatic rectal cancer metastases. Methods 74 patients with hepatic rectal cancer metastases were recruited in our hospital between Jan. 2012 and Jan. 2014，and the participants were randomly divided into two groups. 37 patients in control group were treated with ultrasound-guided radiofrequency ablation under guidance of real time virtual sonography navigation system and FOLFOX6 regimen，and another 37 were given Antike orally after radiofrequency ablation and chemotherapy. All patients were followed-up for two years，and the short-term as well as long-term efficacy was evaluated with RECIST and non-progress free survival（PFS）. Results The total effective rate was 78.4% in the observation group， much higher than 62.2% in the control group （P<0.05）；There was no significant difference as respect to 1 a survival rates in the two groups （89.2% vs. 83.8%，P>0.05），while the 2 a survival rate in the observation group was 67.5%，much higher than 54.1% in the control（P<0.05）；the non-PFS in the observation was 12.4 m（95% CI 10.0～16.2），much longer than 10.1 m in the control（P＜0.05）. Conclusion Antike capsule combined with ultrasound-guided radiofrequency ablation in treatment of patients with hepatic rectal cancer metastases has a good efficacy，and worth to study further in clinical practice.

Key words: Hepatic metastases, Rectal cancer, Radiofrequency ablation, Ultrasound-guidance, Antike capsule, Real time virtual sonography navigation system