Abstract: Objective To investigate the efficacy of radiofrequency ablation （RFA） combined with DC-CIK in the treatment of patients with advanced hepatocellular carcinoma（HCC） and its effect on the quality of life. Methods 144 patients with HCC at ⅢB~Ⅳ stage were recruited in our hospital between September 2013 and September 2016,and were randomly divided into combination and and control group with 72 patients in each group. The patients in both groups were treated with RFA,and 72 out of them received DC-CIK therapy and RFA combination. The quality of life was evaluated by QLQ-C30 questionnaire. Results The objective response rate （ORR） was 70.8%,and the disease control rate （DCR） was 90.3% in the combination group,much higher than 40.3% and 72.2% in the control,and progress-free survival（PFS） was（13.2±3.1） m,much longer than 【（10.5±3.3）m,P<0.05】 in the control;serum AFP,CEA and CA-199 levels were （240.5±28.7） ng/ml,（100.8±20.4） ng/ml and （210.8±52.4） U/ml,much lower than 【（320.4±70.1） ng/ml,（129.4±30.7） ng/ml and （320.7±40.9） U/ml,P<0.05】,respectively in the control;the physical,role’s,emotional,cognitive and social functions in the combination were much higher than those in the control（P<0.05）. Conclusions RFA combined with DC-CIK therapy in the treatment of patients with advanced HCC is in short and long term efficient,which improve the quality of life of the patients.

Key words: Hepatocellular carcinoma, Adoptive immunotherapy, DC-CIK, Radiofrequency ablation, Quality of life