Abstract: Objective To investigate the clinical efficacy of radiofrequency ablation（RFA） combined with transcatheter arterial chemoembolizatio（TACE） in treatment of patients with primary liver cancer （PLC）. Methods 97 patients with PLC were recruited in our hospital between January 2014 and February 2016. 52 patients with PLC received RFA plus TACE and 45 received TACE alone. Serum cytokines were detected by ELISA. The clinical efficacy,changes of peripheral blood T cell subset before and after treatment and life quality after treatment in the two groups were compared. Results The total effective rate in RFA plus TACE group was 67.31%,significantly higher than 40.00% in TACE group（P<0.05）;the disease control rate in combination group was 90.38%,significantly higher than 73.33% in TACE group （P<0.05）;he percentage of CD3⁺T cells,CD4⁺T cells and the ratio of CD4⁺/CD8⁺ 3 months after treatment in combination group were（68.40±10.20）%,45.76±6.83）% and（1.96±0.31）,respectively,all significantly higher than in TACE group[（56.14±6.75）%,（33.27±5.16）% and （1.21±0.22）,P<0.05],while the CD8⁺T cells was （22.08±2.55）%,significantly lower than （28.42±3.97）% in TACE group（P<0.05）;serum levels of IL-6,IL-8 and TNF-α 3 months after treatment in combination group were（129.45±67.14） pg/mL,（0.49±0.13） ng/mL and（134.78±88.20） pg/mL,respectively,significantly lower than in the TACE group [（165.30±65.91） pg/mL,（0.72±0.20） ng/mL and（200.43±84.02） pg/mL,P<0.05];the life quality improvement rate in RFA plus TACE group was 55.77%,significantly higher than 40.00% in TACE group（P<0.05） and the complication occurrence rate was 73.08%,which had no significant difference compared to 71.11% in TACE group. Conclusion RFA combined with TACE has better efficacy in treatment of patients with PLC with improved immune functions and life quality.

Key words: Primary liver cancer, Radiofrequency ablation, Transcatheter arterial chemoembolization, T cell subset, Life quality