Abstract: Objective To study the non-chemotherapeutic factors influencing postoperative nausea and vomiting in patients with hepatocellular carcinoma（HCC） after transcatheter arterial chemoembolization （TACE）. Methods 360 patients with HCC were recruited in our hospital between 2014 and 2016,and we collected the patient’s gender,age,body mass index,right upper quadrant pain,tumor size,the metastasis,fever,abdominal distention,dose of iodized oil,and the Logistic regression analysis was used to analyze the influencing factors of postoperative nausea and vomiting in patients with HCC after TACE. Results According to degree of nausea language description,the grade 2 nausea was found in 58 cases （16.11%）,grade 1 nausea in 83 cases （23.06%）,and grade 0 nausea in 219 cases（60.83%） out of the 360 patients with HCC;the age was negatively correlated（r=-0.303,P<0.05）,while the right upper quadrant pain and abdominal distention were positively correlated to the degree of nausea and vomiting （r=0.299,r=0.497,P<0.05）;the longer the pain lasted, the more severe the nausea and vomiting（r=-0.203,P<0.05）;Logistic analysis showed that the elderly was a protected factor for the occurrence of nausea and vomiting in patients with HCC after TACE, while long time abdominal pain and distention were the independent factors for it; the results of the structural equation model showed that the abdominal pain and distention stimulated nausea and vomiting （β=0.39,β=0.69,P<0.01）,age promoted abdominal distention （β=0.02,P<0.01）,while age down-regulated abdominal pain （β=-0.02,P<0.01）. Conclusion There are a variety of factors including age,abdominal pain and abdominal distention involved in the occurrence of nausea and vomiting in patients with HCC after TACE, and the old age is a protective factor of postoperative nausea and vomiting,while the long time abdominal pain and abdominal distention are the risk factors for it.

Key words: Hepatocellular carcinoma, Transcatheter arterial chemoembolization, Nausea and vomiting, Influencing factors