Abstract: Objectiv To analyze the factors influencing liver stiffness measurement （LSM） in patients with chronic hepatitits B （CHB） and liver cirrhosis （LC） in Tibet. Methods 70 patients with CHB and 30 with LC were recruied in Traditional Tibetan Medicine Hospital between January 2017 and March 2018,and FibroScan was used to detect LSM in all the patients. Serum markers of liver function,renal function,blood lipids,blood glucose,blood coagulation function and blood routine examination,and ultrasonic examination were evaluated. Result The LSM was（7.17±12.19） kPa in patients with CHB,significantly lower than 【（14.92±14.01）kPa,P<0.05】 in patients with LC,and the CAP was （210.70±66.22） db/m,not significantly different as compared to （212.00±69.20） db/m in patients with LC（P>0.05）;the APTT,AST,ALP,GGT,GLOB,TBIL and TBA were positively correlated,and WBC,PLT,HGB,PTA,FIB,ALB,GFR and LDL-C were negatively correlated to LSM（P<0.05）,while body mass,ALT,UREA,CREA,UA,TG,HDL-C,GLU,AMY and controlled attenuation parameter were not statistically significantly correlated to LSM（P>0.05）;multivariate regression analysis showed that age（P=0.003）,hepatic echo enhancement （P=0.020）,hepatic echo nodule （P=0.000）,PT （P=0.007）and TBA （P=0.004） were the independent factors influencing the LSM in patients with hepatitis B viral infection. Conclusion Clinicians should take the influencing factors of LSM into consideration in clinical practice in order to deal with the patients properly in time.

Key words: Liver cirrhosis, Hepatitis B, Liver stiffness measurement, Influencing factors