Abstract: Objective To compare laparoscopic left hepatic resection（LLLR） and laparoscopic left hepatic resection （OLLR） in treatment of patients with left lateral lobe hepatocellular carcinoma （HCC）. Methods 94 patients with left lateral HCC in our hospital between April 2011 and June 2013 were recruited in this study,and they were randomly divided into control and observation group,with 47 cases in each group. The patients in control group received OLLR,and those in observation group were treated with LLLR. Serum ICAM-1,MMP-13 and IL-6 levels were detected by ELISA. All patients were followed-up for 3 years,and the survival rates at 1 year,2 years and 3 years after operation were recorded. Results The amount of bleeding in the observation group was （134.94±23.51） ml,significantly lower than in the control group [（290.18±30.76） ml,P<0.01],eating after operation was（2.29±0.51） d,significantly shorter than in the control group[（3.80±0.87） d,P<0.01], hospitalization stay was（7.43±2.39） d,significantly shorter than in the control group [（11.42±3.08） d,P<0.01]; serum ICAM-1 levels after operation in observation group was （8.08±2.13） ng/ml,significantly lower than in the control group [（3.27±2.60） ng/ml,P<0.01],MMP-13 was（113.65±21.92） ng/ml,significantly lower than in the control group [（171.02±27.85） ng/ml,P<0.01], PCT was （7.23±0.74） g/L,significantly lower than in the control group [（11.24±1.53） g/L,P<0.01],IL-6 was （11.49±2.78） pg/L, significantly lower than in the control group [（19.06±3.27） pg/L,P<0.01];serum IgA,IgM and IgG levels were significantly higher than in the control group （P<0.01）;the incidence of complica-tions in the observation group （12.8%） was signifi-cantly lower than in the control group （42.5%,P<0.05）;there was no significant difference as respect to the survival rates between the two groups in three year follow-up. Conclusion LLLR is an alternative approaches in the treatment of patients with left lateral lobe HCC,as it could significantly reduce the postoperative complications,inflammatory reactions and protect the immune functions with the similar long-term efficacy.

Key words: Hepatoma, Laparoscopic left hepatic resection, Laparoscopic left hepatic resection, Complication, Survival rate