肝纤维化进程中细胞外基质对肝星状细胞的作用及机制研究进展*

doi:10.3969/j.issn.1672-5069.2017.03.037

Abstract

Abstract: Liver fibrosis is a pathological process characterized by intrahepatic diffuse excess deposition of extracellular matrix（ECM）,and hepatic stellate cells （HSC） activation. This article mainly reviewed the changes of various components of ECM,the molecular structure and the spatial structure of the ECM in the process of hepatic fibrosis. And we also summarized the mechanism by which the effects of these changes on the activation,proliferation and apoptosis of HSCs.

Key words: Liver fibrosis, Extracellular matrix, Hepatic stellate cell

Qin Yumeng, Chen Shenghua. Influence of extracellular matrix on hepatic stellate cells during liver fibrosis process[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(3): 381-384.

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Influence of extracellular matrix on hepatic stellate cells during liver fibrosis process

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