炎症小体与非酒精性脂肪性肝炎

doi:10.3969/j.issn.1672-5069.2017.03.036

Abstract

Abstract: Nonalcoholic steatohepatitis（NASH） is one of the most common cause of chronic liver disease worldwide. The pathogenesis of NASH includes inflammasomes signal pathway at the base of two-hit theory. The inflammasomes are multiprotein complexes that can sense danger signals from damaged cells and stimulate inflammatory cascade,thereby aggravating liver damage. In this review,we discuss the roles of neutrophilic alkaline phosphatase（NALP3）,NALP6 and absent in melanoma 2 （AIM2） inflammasome signal pathway in the pathogenesis of NASH.

Key words: Nonalcoholic steatohepatitis, Neutrophilic alkaline phosphatase 3, Neutrophilic alkaline phosphatase 6, Absent in melanoma 2

Jia Yanhong, Li Xiangqian, Zhao Caiyan. Inflammasome in the pathogenesis of nonalcoholic steatohepatitis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2017, 20(3): 377-380.

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Inflammasome in the pathogenesis of nonalcoholic steatohepatitis

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