Abstract: Objective To investigate the changes of serum biochemical indexes and its impact on perinatal prognosis neonates in mothers with intrahepatic cholestasis of pregnancy（ICP）.Methods A total 102 women with ICP were recruited in Maternal and Child Health Care Hospital between January 2013 and January 2015 in this study，and the clinical materials were retrospectively analyzed. The patients were divided into mild （n=75） and severe ICP group （n=27） according to the levels of total bile acids （TBA） and cholyglycine （CG），and they were also divided into early-onset （n=23，onset less than 28 gestational weeks） and late-onset ICP group （n=79，onset longer than 28 gestational weeks） according to the onset of ICP. 50 normal pregnant women in the same period were enrolled as controls. The levels of maternal serum TBA，CG and liver function index [aspartate aminotransferase （AST），alanine aminotransferase （ALT），total bilirubin （TBIL），gamma-glutamyl transferase （GGT）] were compared among the mild，severe and control group. The relationship between onset of ICP and severity of the disease was analyzed and the perinatal outcome were assessed.Results Serum levels of TBA，AST，ALT，TBIL and GGT of mothers in mild and severe ICP group were significantly higher than those of mothers in control group （t=6.06～29.13，P<0.01），and the above index in severe ICP group were significantly higher than those of mothers in mild ICP group （t=2.23～18.87，P<0.01）； The incidence rate of severe ICP in mothers of early-onset group was 47.8%，significantly higher than 20.3% of mothers in late onset group（x2=6.96，P<0.01），and the onset time of ICP was closely related to the severity of the disease；Compared with mothers in control group，the pregnant weeks，birth weight，1 min Apgar score were significantly reduced（t=2.63～10.52，P<0.01） and the postpartum hemorrhage amounts were significantly increased（t=7.43，t=10.22，P<0.01） of mothers in mild ICP group and severe ICP group；The pregnant weeks，birth weight，1 min Apgar score in severe ICP group[（36.2±1.7） w，（2876±115） g and （7.86±0.60）] were significantly lower than those of mothers in mild ICP group [（37.5±1.6） w，（3040±135） g and （9.02±0.58），t=3.56～8.83，P<0.01]；The amniotic fluid pollution rate was 25.3% in mothers with mild ICP，much higher than 10.0% （x2=6.96，P<0.01） in mothers in control group，the preterm labor，amniotic fluid pollution，fetal distress，cesarean section and neonatal mortality rates（37.0%，40.7%，29.6%，63.0% and 14.4%） in mothers in severe ICP group were significantly higher than those（6.0%，10.0%，6.0%，16.0% and 0.0%，x2=5.09～17.64，P<0.05 or P<0.01） in control group；The rates of preterm labor，fetal distress and cesarean section（37.0%，29.6% and 63.0%） in mothers in severe ICP group were significantly higher than those（16.0%，12.0% and 26.7%，x2=4.44～11.31，P<0.05 or P<0.01） in mothers in mild ICP group.Conclusions The onset of ICP，levels of maternal TBA，CGA and liver function are related to the severity of ICP，and ICP increases the risk of perinatal birth and affects the growth and development of infants.

Key words: Intrahepatic cholestasis of pregnancy, Total bile acids, Cholyglycine, Liver function, Perinatal prognosis