Abstract: Objective To analyze the changes of serum platelet derived growth factor （PDGF） and folic acid in patients with hepatitis B-induced liver cirrhosis. Methods 110 patients with hepatitis B-induced liver cirrhosis with normal renal functions between January 2015 and December 2016 were included in this study. Patients were divided into three groups based on Child-Pugh class. Serum PDGF,folic acid,liver function index,liver fibrosis index were routinely determined. Correlation of serum PDGF and folic acid levels with liver function index, liver fibrosis index were determined by using Pearson correlation analysis. Results Serum PDGF level in 32 patients with Child-Pugh class C was （190.7±11.4） pg/ml,which was much higher than （128.5±8.1） pg/ml in 42 patients with Child-Pugh class B or（79.5±4.9） pg/ml in 36 patients with Child-Pugh class A（P﹤0.05）;serum folic acid levels in patients with Child-Pugh class C was（2.7±0.5） g/L,which was lower than（5.3±0.5）μg/L in patients with Child-Pugh class B or（7.1±0.8） μg/L in Child-Pugh class A（all P﹤0.05）;serum alanine aminotransferase （ALT）,total bilirubin （TBIL） level and INR in patients with Child-Pugh class C were （102.4±6.9） U/L,（60.7±5.8） μmol/L and （1.9±0.2）,respectively,which were much higher than [（78.9±4.5）U/L,（36.4±3.2） μmol/L and （1.5±0.2）,respectively] in patients with Child-Pugh class B or [（56.8±3.9） U/L,（26.8±2.8） μmol/L and （1.2±0.1）,respectively] in Child-Pugh class A （all P﹤0.05）;serum albumin level in patients with Child-Pugh class C was（23.9±2.4） g/L,which was lower than （30.8±2.7） g/L in patients with Child-Pugh class B or in Child-Pugh class A [（41.0±3.3） g/L,P﹤0.05];serum type Ⅲ procollagen （PCⅢ）,collagen Ⅳ（Ⅳ-C）,laminin（LN） and hyaluronidase（HA） levels in patients with Child-Pugh class C were（279.7±19.2） μg/L,（140.4±8.0） μg/L,（159.7±8.2） μg/L and（237.8±9.1）μg/L,which were much higher than[（238.5±17.8） μg/L,（94.8±6.2） μg/L,（129.5±7.3） μg/L and （174.1±8.6）μg/L] in patients with Child-Pugh class B or [（158.6±13.6） μg/L,（75.4±5.1） μg/L,（96.8±6.8） μg/L and （128.3±6.9）μg/L] in patients with Child-Pugh class A （all P﹤0.05）;serum PDGF levels was positively correlated with serum ALT,TBIL,INR and liver fibrosis index and negatively correlated with ALB（all P﹤0.05）;serum folic acid level was negatively correlated with serum ALT, TBIL,INR and liver fibrosis index and positively correlated with serum ALB level（all P﹤0.05）. Conclusion Serum PDGF levels increase and folic acid decrease as the liver function deteriorates,which warrants further study.

Key words: Liver cirrhosis, Hepatitis B, Platelet derived growth factor, Folic acid, Liver function classification