Abstract: Objective To assess the state of gut inflammation in patients with non-alcoholic fatty liver diseae （NAFLD） by using fecal calprotectin measurement. Methods In NAFLD patients and healthy persons,the fecal calprotectin levels were measured by enzyme-linked immunosorbent assay,and the demographic data and biochemical parameters were collected. Results Eighty-one NAFLD patients and 91 healthy subjects were recruited in this study. The body mass index（BMI） in the healthy controls and in the NAFLD patients were （22.6±2.4） kg/m² vs. （28.5±4.0） kg/m²,waist circumference were（80.9±7.9） cm vs. （91.6±9.5） cm,AST was （19.3±4.8） IU/L vs. （33.7±18.7） IU/L,ALT was （17.5±7.1） IU/L vs. （55.0±44.5） IU/L,TG was（0.9±0.3） mmol/L vs. （2.4±2.3） mmol/L,TC was（4.3±0.6） mmol/L vs. （5.1±1.3） mmol/L,all of the difference were statistically significant（P<0.05）;the fecal calprotectin levels in the patients with NAFLD was 43.0（18.8~87.0）μg/g,much higher than 11.4（4.6~24.4） μg/g in the control （P<0.001）;There were positive correlations between fecal calprotectin levels and BMI,waist circumference,TC and GGT（r=0.725,r=0.570,r=0.292,and r=0.400,respectively,all P<0.010）;Multivariate analysis demonstrated that a low level of HDL,and a high level of TG,BMI,and TC were independent risk factors for NAFLD（OR=0.011,OR=3.558,OR=1.821,OR=3.086,respectively,all P<0.01）. Conclusion Fecal calprotectin levles increases in NAFLD patients,which might reflect the inflammation state of the gut.

Key words: Nonalcoholic fatty liver disease, Fecal calprotectin, Gut inflammation