Abstract: Objectiv To explore the impact of nutrition support and medusa administration on liver function, erythrocyte and platelet parameters in patients with alcoholic liver diseases（ALD）. Methods 90 patients with ALD were recruited in our hospital between May 2015 and October 2017,and they were divided into two groups with 45 cases in each group. All the patients were given glutathione,portuguese aldehyde lactone intravenously and 45 patients were treated with metadoxine,while another 45 were treated with combination of metadoxine and nutritional support at 35~40 kcat·kg^-1·d^-1. The regimen lasted for four weeks. Results At presentation,serum liver function and blood coagulation function index in the two groups were not statistically significantly different （P>0.05）,while serum ALT,GGT and bilirubin levels at the end of the treatment in the two groups significantly decreased and coagulation function improved;before the treatment,the red blood cell parameters,including RBC counts,HBG levels,HCT,RDW and MCV in the two groups had no statistically significantly different（P>0.05）,while at the end of the treatment,the RBC counts,HBG and HCT in the two groups were significantly increased,e.g.（3.45±0.46）×10¹²/L vs. （5.32±0.51）×10¹²/L,（90.12±3.67） g/L vs. （140.92±6.02） g/L,（0.32±0.12）% vs. （0.46±0.11） % in the combination group,and（3.44±0.42）×10¹²/L vs. （4.96±0.48）×10¹²/L,（89.92±3.54）g/L vs. （135.67±6.23） g/L,（0.32±0.10）% vs. （0.41±0.10） % in metadoxine-treated group,and MCV and RDW decreased,e.g. （19.34±1.92）% vs. （12.43±1.21）% and（109.24±6.34）fL vs. （95.19±5.92） fL in the combination,and （19.15±1.89）% vs. （14.91±1.19）% and （109.01±6.45）fL vs. （99.43±6.42）fL in the metadoxine-treated group （P<0.05）;Before the treatment,the platelet parameters,such as PLT counts,MPV and PDW had no statistically significantly different （P>0.05）,and at the end of the treatment,the platelet counts significantly increased in the two groups,e.g. （98.43±10.02）×10⁹/L vs. （219.04±9.78）×10⁹/L in the combination group,an （98.68±10.13）×10⁹/L vs. （200.43±10.24）×10⁹/L in metadoxine-treated group（P<0.05）,while the MPV and PDW decreased obviously,e.g.（12.74±2.02） fL vs.（10.76±1.13） fL and （17.93±2.01） fL vs. （14.28±1.45） fL in the combination group,and（12.84±2.11） fL vs.（11.63±1.02） fL,and （17.87±1.98） fL vs. （15.89±1.51） fL in metadoxine-treated group （P<0.05）;All the improvements above in combination group were significantly superior to those in metadoxine-treated group （P<0.05）. Conclusion The metadoxine combined with nutrition support in treatment of patients with ALD might significantly improve the liver function,erythrocyte and platelet parameters,which needs further and long-term investigation.

Key words: Alcoholic liver diseases, Metadoxin, Nutritional support, Liver function, Red blood cells, Platelet parameters