Abstract: Objective To explore the changes of estimated glomerular filtration rates（eGFR） in healthy check-up adults with nonalcoholic fatty liver diseases（NAFLD）.Methods Six hundred individuals underwent routine check-up，and 292 without history of alcohol consumption，liver diseases and kidney diseases were enrolled in this study. Nonalcoholic fatty liver disease was diagnosed by B-mode ultrasound. Controlled attenuation parameter（CAP） was measured by FibroScan and blood biochemistry tests were routinely assayed. The eGFR was calculated.Results A total of 154 patients（52.7%） were found to have NAFLD out of 292 participants. The body mass index，waist circumference，blood haemoglobin，alanine aminotransferase，aspartate aminotransferase，gamma-glutamyltransferase，urea acid，and triglyceride were significantly increased in the NAFLD group as compared to 138 controls without NAFLD；eGFR in the NAFLD group was significantly lower than that in the control group [（107.95±35.38 mL.min-1. per 1.73 m2 vs. 122.95 66.19 mL.min-1. per 1.73 m2，P<0.05]；The eGFR was negatively correlated with CAP （r=-0.137，P=0.137），and the eGFR was decreased sharply with increased CAP value in this 292 check-up individuals；There was no significant difference as respect to gender，age，blood urea nitrogen， serum creatinine levels between groups of NAFLD and control；The multivariate Logistic regression analysis showed that gender，age，serum creatinine levels and CAP were independent factors for renal damage in patients with NAFLD.Conclusion The findings in our study suggest that mild renal function reduction presenting with decreased eGFR exists in patients with NAFLD. Therefore，prevention of chronic kidney disease is necessary in patients with NAFLD.

Key words: Nonalcoholic fatty liver diseases, Controlled attenuation parameter, Estimated glomerular filtration rates