Abstract: Objective To explore the reliability of serum people end limb homologous protein 2 （Pygo2） levels in diagnosis of liver fibrosis in patients with chronic hepatitis C（CHC）.Methods 90 patients with CHC were enrolled in this study， and they were divided into F0，F1，F2，F3 and F4 hepatic fibrosis according to liver fibrosis scores. Serum Pygo2 levels were tested by enzyme-linked immunosorbent assay，and the correlation between serum Pygo2 levels and liver fibrosis staging was performed. With liver biopsy as the gold standard of diagnosis，the ROC curves were delineated and the area under the curves（AUC） was calculated to evaluate the diagnostic efficacy for liver fibrosis.Results Out of 90 patients with CHC，the histopathological examination found F0 in 6 cases （6.7%），F1 in 13 （14.4%），F2 in 26（28.9%），F3 in 35 （38.9%） and F4 in 10（11.1%）；Serum Pygo2 levels in F2 group was higher than that in F1 [（70.1±19.8） ng/ml vs. （55.9±20.4） ng/ml，P＜0.05]，serum Pygo2 levels [（100.1±24.6） ng/ml] in F3 was significantly higher than that in F2（P＜0.001），and serum Pygo2 levels in F4 [（145.6±45.7） ng/ml] was much higher than in F3 （P＜0.01）；There were a statistically positive correlation between serum Pygo2 levels and hepatic fibrosis staging（r=0.704，P＜0.01）；assuming serum Pygo2 levels ≥69.1 ng/mL，≥83.9 ng/mL and ≥109.60ng/mL as the cut-off-value for diagnosis of obvious（F≥2） and severe liver fibrosis （F≥3） or liver cirrosis （F=4），the AUC of ROC curves were 0.8824 （95% CI:0.806～0.959），0.9004 （95% CI:0.836～0.964） and 0.8834 （95% CI:0.768～0.999），respectively.Conclusion Serum Pygo2 level could be used to diagnose liver fibrosis in patients with CHC， which warrants further study.

Key words: Chronic hepatitis C, Hepatic fibrosis, People end limb homologous protein 2, Diagnosis