Abstract: Objective This study was aimed to determine the correlation between controlled attenuation parameters（CAPs） of spleen and liver,and investigate the influencing factors in the detections. Methods A total of 274 patients with chronic liver diseases and spleen parenchyma thickness >4 cm were included in this study. We used FibroTouch to measure the stiffness and CAP values of liver and spleen. Then,we tried to find the correlation between liver and spleen measurements by Pearson correlation analysis. Results The success rate of the liver detection was 100%,while the success rate of the spleen detection was 77.37%;The stiffness values of liver and spleen were（10.07±7.04）kPa and （21.34±19.41）kPa respectively,and they were significant correlated （r=0.548,P<0.000） and the CAP values of liver and spleen were（235.90±54.40） dB/m and （245.45±66.59） dB/m respectively,and they had a significant correlation too（r=0.443,P<0.000）;in patients with BMI<24 kg/m²,24~28 kg/m² and≥28 kg/m²,the liver CAP were （217.0±45.8）dB/m,（251.6±52.8）dB/m and （299.2±46.0）dB/m;in patients with skin to liver capsule depth（SCD）≤20 mm,20~25 mm and ≥25 mm,the liver CAP were （204.5±26.5）dB/m,（237.9±31.1）dB/m and （268.9±60.7）dB/m,suggesting they increased with the increase of BMI and SCD; The spleen CAP in each group of BMI<24 kg/m²,24~28 kg/m² and ≥28 kg/m² were （230.4±68.9）dB/m,（261.8±52.8）dB/m and（288.2±41.5）dB/m;Liver CAP in each group of SCD≤20 mm,20~25 mm and≥25 mm were （229.8±68.4）dB/m,（262.2±54.3）dB/m and（258.4±60.2）dB/m,suggesting they increased with the increase of BMI,but had no significant difference in the group of SCD<25 mm and SCD≥25 mm;The multivariate linear regression showed that BMI was the independent factor of liver CAP,while high-density lipoprotein was the independent factor of spleen CAP. Conclusion FT can be used to detect the liver CAP in almost all and spleen CAP in most of patients with chronic liver diseases,and the application of the latter in diagnosis of liver diseases needs to further investigation.

Key words: Fatty liver diseases, FibroTouch, Spleen, Controlled attenuation parameter, Influencing factors