Abstract: Objective To study the therapeutic effect of YinChen water extracts in rats with bovine serum albumin-induced liver fibrosis. Methods 90 SD rats were randomly divided into normal control,model,colchicines,and large（200 mg·kg^-1）,middle（100 mg·kg^-1） and low （50 mg·kg^-1） dose of YinChen water extracts intervened groups. The medicine and herbal medicine were intragastricly administered after the model had been successfully established. Serum PC III,IV-C collagen,LN,HA and hepatic hydroxyproline content were detected. The liver histopathological changes were also observed. Results The levels of serum ALT,AST,PC-Ⅲ,Ⅳ-C,LN,HA and liver tissue hydroxyproline content were（103.78±19.83） IU/L,（246.53±36.67） IU/L,（30.34±2.52） ng/ml,（29.54±2.65） ng/ml,（45.34±1.45） ng/ml,（232.51±23.66） ng/ml and （0.85±0.22） μg/mg in the large dose YinChen water extracts group,and they were（124.59±24.41） IU/L,（277.23±36.45） IU/L,（34.57±2.34） ng/ml,（34.90±2.45） ng/mL,（52.13±2.34） ng/ml,（283.14±23.75） ng/ml and（0.96±0.26） μg/mg in the middle dose group, much lower than in the model group[（161.24±26.23） IU/L,（382.45±39.45） IU/L,（41.78±3.12） ng/ml,（42.34±3.25） ng/ml,（65.14±3.81） ng/ml,（383.53±39.35） ng/ml and （1.43±0.17） μg/mg,P<0.05];serum levels of albumin in large and middle groups were （35.66±2.85）g/L and （35.78±2.64）g/L, significantly higher than in the model group[（31.32±2.15）g/L,P<0.05];Pathological examination showed that hepatic cells edema,degeneration and necrosis in colchicines,large and middle dose of YinChen water extract groups appeared significantly improved as compared with in the model group. Conclusion The YinChen water extracts has a certain therapeutic effect on liver fibrosis,and it is worth to be further studied.

Key words: Liver fibrosis, Herbal medicine, Bovine serum albumin, Immunological liver injuries, Rats