枯否氏细胞在肝损伤中的作用研究进展

doi:10.3969/j.issn.1672-5069.2016.05.034

Abstract

Abstract: Kupffer cells serve as a protective barrier in the liver tissues. In endotoxinemia-induced liver injury,Kupffer cells produce pro-inflammatory cytokines and other chemical factors as they coupled with pattern recognition receptors such as Toll-like receptor,which can accelerate the processing of liver injury. Conversely,in drug-induced liver injury,such as acetaminophen-induced liver injury,Kupffer cells play several protective roles via secreting anti-inflammatory cytokines and promoting the formation of blood vessels in liver tissues. In this paper,we reviewed the vital role of Kupffer cells in the two types of liver injuries.

Key words: Liver injuries, Kupffer cells, Endotoxinemia, Acetaminophen

You Na, Zhu Jin, Wang Maorong.. Roles of Kupffer cells in liver injuries[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(5): 633-636.

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Roles of Kupffer cells in liver injuries

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