Abstract: Objective To observe incidence and management of liver injuries in patients with tuberculosis complicated with hepatitis B viral infection during antituberculosis therapy. Methods 823 patients with tuberculosis were divited into group A without HBV infection,group B with HBsAg positive and HBV DNA negative，and group C and D with HBsAg and HBV DNA positive. All patients received anti-tuberculosis therapy，except patients in group D who were treated with nucleoside analogue one week before anti-tuberculosis treatment. Results The incidence of liver injuries in four groups were 28.1%，32.1%，65.4% and 29.2%（P<0.001 as group C was compared with other three groups）；The incidence of liver injuries in four groups at an half month of treatment were 5.7%，22.2%，70.6% and 14.3%（P<0.001）.Conclusion The patients with tuberculosis and HBV infection have high incidence of liver damage during antituberculosis therapy. The administration of nucleoside analogue in time might decrease the incidence of liver injuries.

Key words: Tuberculosis, HbsAg, Liver injuries, Nucleoside analogue