肝衰竭预后模型研究新进展

doi:10.3969/j.issn.1672-5069.2016.04.034

Abstract

Abstract: There are many complications in patients with liver failure,which might lead to high mortality. Assessing the prognosis of patients with liver failure in time and accurately is very important for this kind of patients. Here we reviewed the new models in recent years,including the advantages,disadvantages and the use of conditions of MELD score, SOFA score, improved SOFA score,and ALFED model. We also discussed some new biological markers of liver failure.

Key words: Liver failure, Prognosis, Model, Biological markers

Ni Qingtao, Yang Yongfeng. Insight into the study of prognosis model for patients with liver failure[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(4): 500-504.

References

[1] 中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南.实用肝脏病杂志,2013,16（3）:210-216.
[2] Shakil A,Kramer D,Mazariegos G,et al.Acute liver failure: clinical features,outcome analysis,and applicability of prognostic criteria. Liver Transplant,2000,6（2）:163-169.
[3] Malinchoc M,Kamath PS,Gordon FD,et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts.Hepatology,2000,31（4）:864- 871.
[4] Kamath PS,Wiesner RH,Mallnchoc M,et al. A model to predict survival in patients with end-stage liver disease. Hepatology,2001,33（2）:464-470.
[5] Boone MD,Celi LA,Ho BG,et al. Model for end-stage liver disease score predicts mortality in critically ill cirrhotic patients. J Crit Care,2014,29（5）:881.e7-e13.
[6] Hye SS,Sae PK,Sang HH,et al. Prognostic indicators for acute liver failure development and mortality in patients with hepatitis A:Consecutive case analysis. Yonsei Med J,2014,55（4）:953-959.
[7] Wang X,Wang BM,Li B,et al. A clinical prediction model and its application for bleeding in chronic liver failure patients with esophageal varices. Eur Rev Med Pharmacol Sci,2013,17（22）:3046-3055.
[8] Lee HS,Choi GH,Joo DJ,et al. Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure. Transplant Proc,2013,45（8）:2992-2994.
[9] Ha JM,Sohn W,Cho JY,et al. Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure. Clin Mol Hepatol,2015,21（3）:232-241.
[10] McPhail MJ, Farne H,Senvar N,et al. Ability of King's college criteria and model for end-stage liver disease scores to predict mortality of patients with acute liver failure:A Meta-analysis. Clin Gastroenterol Hepatol,2015,20.pii:S1542-3565（15）01403-2.doi:10.1016.
[11] Murugesh M,Niraj RS,Madhu S,et al. Retrospective and prospective validation of model for end-stage liver disease （MELD） score in predicting mortality in patients of alcoholic liver disease. Trop Gastroenterol,2013,34（4）:252-258.
[12] Selcuk H,Uruc I,Temel MA,et al. Factors prognostic of survival in patients awaiting liver transplantation for end-stage liver disease. Dig Dis Sci,2007,52（11）:3217-3223.
[13] Huadong Y,Wu W,Yang Y,et al. A novel integrated Model for end-stage liver disease model predicts short-term prognosis of hepatitis B virus-related acute-on-chronic liver failure patients. Hepatol Res,2015,45（4）:405-414.
[14] Vincent JL,Moreno R,Takala J,et al. The SOFA（Sepsis- related organ failure assessment） score to describe organ dysfunction/failure. Working Group on“sepsisrelated problems”of the European Society of Intensive Care Medicine. Int Care Med,1996,22（7）:707-710.
[15] Cholongitas EB,Betrossian A,Leandro G,et al. King’s criteria, APACHE II,and SOFA scores in acute liver failure. Hepatology,2006,43（4）:881-882.
[16] Vincent JL,de Mendonca A,Cantraine F,et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units:results of a multicenter,prospective study. Working group on“sepsis- related problems”of the European Society of Intensive Care Medicine. Crit Care Med,1998,26（11）:1793-1800.
[17] Frhlich S,Murphy N,Kong T,et al. Alcoholic liver disease in the intensive care unit：outcomes and predictors of prognosis. J Crit Care,2014,29（6）:1131.e7-e13.
[18] Moreau R,Jalan R,Gines P,et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology,2013,144:1426-37 1437.e1-9.
[19] Pan HC,Jenq CC,Tsai MH,et al. Scoring systems for 6-month mortality in critically ill cirrhotic patients:a prospective analysis of chronic liver failure sequential organ failure assessment score （CLIF-SOFA）. Aliment Pharmacol Therapeut,2014,40（9）:1056-1065.
[20] McPhail MJ,Shawcross DL,Abeles RD,et al. Increased survival for patients with cirrhosis and organ failure in liver intensive care and validation of the chronic liver failure-sequential organ failure scoring system. Clin Gastroenterol Hepatol,2015,13（7）:1353-1360.
[21] Kumar R,Shalimar H,Sharma H,et al. Prospective derivation and validation of early dynamic model for predicting outcome in patients with acute liver failure. Gut,2012,61（7）:1068-1075.
[22] Naiki T,Nakayama N,Mochida S,et al. Novel scoring system as a useful model to predict the outcome of patients with acute liver failure:Application to indication criteria for liver transplantation.Hepatol Res,2012,42（1）:68-75.
[23] 段钟平,郑素军,陈鹏,等. 肝衰竭预后评价新标志物研究进展.传染病信息,2009,22（5）:265-268.
[24] Schidt FV,Ostapowicz G,Murray N,et al. Alpha-fetoproteinand prognosis in acute liver failure. Liver Transplant,2006,12（12）:1776-1781.
[25] Jorge LV,Norberto CT,Guadalupe PR,et al. Bilirubin alone as a biomarker for short-term mortality in acute-on-chronic liver failure:an important prognostic indicator. Ann Hepatol,2014,13（1）: 98-104.
[26] Macquillan GC,Seyam MS,Nightingale P,et al. Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure.Liver Transplant,2005,11（9）:1073-1079.
[27] Li YL,Chang CJ,Cheng SL,et al. Proteinuria can predict short-term prognosis in critically ill cirrhotic patients. Clin Gastroenterol,2014,48（4）:377-382.
[28] Bernal W,Hall C,Karvellas CJ,et al. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure.Hepatology,2007,46（6）:1844-1852.
[29] Liu H,Zhang H,Wan G,et al. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. J Viral Hepat,2013,21（7）:499-507.
[30] Wang K,Wu ZB,Ye YN,et al. Plasma interleukin-10:A likely predictive marker for hepatitis B virus-related acute-on-chronic liver failure. Hepat Month,2014,14（7）:e19370.
[31] Feng HL,Li Q,Wang L,et al. Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure. Hepatobiliary Pancreat Dis Int,2014,13（3）:271-275.
[32] Nakamura M. Clinical significance of autoantibodies in primary biliary cirrhosis. Sem Liver Dis,2014,34（3）:334-340.
[33] Gao S,Ji X,Ji F,et al. Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-on-chronic hepatitis B liver failure.J Viral Hepat,2015,22（2）:112-119.
[34] Stauber RE,Walter S,Josef H,et al. Human nonmercaptalbumin-2:A novel prognostic marker in chronic liver failure. Therapeut Apher Dial,2014,18（1）:74-78.
[35] 郑以山,吴宗盛,杨永峰,等. 血浆半乳糖凝集素-3水平对慢加亚急性肝衰竭预后的判断作用.中华肝脏病杂志,2014,22（4）:295-298.

Insight into the study of prognosis model for patients with liver failure

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Zhu Yucheng, Yan Jiawei, Sun Jingkun, et al. Serum diamine oxidase level in patients with hepatitis B-induced acute-on-chronic liver failure [J]. Journal of Practical Hepatology, 2019, 22(5): 672-675.
[2]	Song Haiyan, Chen Xi, Zhang Junfei, et al. Application of vorionazole in the treatment of patients with liver failure complicated by pulmonary fungal infection [J]. Journal of Practical Hepatology, 2019, 22(5): 676-679.
[3]	Huang Hanjun, Lu Fengrong, Zhang Can. Clinical value of MRI scanning based on exchange hemodynamics model in evaluating liver cirrhosis [J]. Journal of Practical Hepatology, 2019, 22(5): 696-699.
[4]	Wang Gang, Zhao Hongbo, Zhu Yaling, et al. Cancerous XPO5 gene level in patients with hepatocellular carcinoma and its clinical significance [J]. Journal of Practical Hepatology, 2019, 22(5): 724-727.
[5]	Zhang Xuan, Tang Xiaoyun, Tang Chunyin, et al. Effect of Chinese herbal medicine on intestinal microflora in mice with D-galactosamine/LPS-induced acute liver failure [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 478-481.
[6]	Yu Yingfang, Wen Shengbao. Assessment of liver fibrosis with diffusion-weighted magnetic resonance imaging using single, double and stretch index model in patients with chronic hepatitis B [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 502-505.
[7]	Zhuang Taiping, Yin Yangyan, Xie Manfang, et al. Comparison of clinical features of infants with human cytomegalovirus infection and of infantile hepatitis syndrome [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 514-517.
[8]	Wang Yuan, Dang Panyu, Wang Wei. Application of plasma exchange and continuous plasma dialysis filtration in the treatment of patients with acute-on-chronic liver failure [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 541-544.
[9]	Peng Silu, Liu Bing, Sun Hong, et al. Prognosis of patients with hepatitis B-induced acute-on-chronic liver failure [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 545-548.
[10]	Zhong Song, Liu Yuyuan, Liu Shuren. G2D expression of peripheral blood natural killer cells in patients with chronic hepatitis B [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 341-344.
[11]	Pan Jinjin, Dong Jing, Song Haiyan. Clinical efficacy of glucosteroid on blocking disease progress in patients with nucleos（t）ide analogue withdrawal hepatitis [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 357-360.
[12]	Qiao Zhizhong. Value of contrast-enhanced ultrasonography in differential diagnosis of patients with focal nodular hyperplasia and hepatocellular carcinoma [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 421-424.
[13]	Zhang Tingting, Wang Xuan. Clinical implications of oral glucose tolerance test in cirrhotic patients with hepatogenous diabetes [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 449-452.
[14]	Guideline for diagnosis, treatment of liver failure. [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 164-171.
[15]	Song Fangjiao, Zhu Bing, Lyu Sa, Tian Hua, Wang Haibo, Xin Shaojie, You Shaoli. Clinical analysis of drug-induced liver failure：a report of 314 cases [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 216-219.