Abstract: Objective To investigate the clinical application of ultrasonography in the diagnosis of patients with cirrhosis and portal hypertension. Methods 80 patients with liver cirrhosis and portal hypertension were recruited in our hospital between January 2008 and September 2015,and 75 healthy persons were included as control.The degree of esophageal-gastric varices was observed by endoscopy,and the portal vein diameters, splenic vein diameters,portal vein blood flow and splenic vein blood flow were determined by ultrasonography in the two groups. Results The diameter of portal vein was （1.4±0.6）cm,the diameter of splenic vein was （1.2±0.3）cm,the portal vein blood flow was （1023.2±653.4） mL/min,and the splenic vein blood flow was （593.3±112.3）mL/min in patients with cirrhosis,while the diameter of portal vein was（0.9±0.2）cm,the diameter of splenic vein was （0.6±0.4）cm,the portal vein blood flow was （916.3±254.2） mL/min,and the splenic vein blood flow was （325.6±96.4）mL/min in healthy persons （P<0.05）;the incidence of mild varices in 46 patients with portal vein diameter≥1.4cm was 19.6%,significantly lower than 52.9% in 34 patients with portal vein diameter <1.4cm（P<0.05）,and the incidence of severe varices in patients with portal vein diameter≥1.4cm was 52.2%,much higher than 20.6% in patients with portal vein diameter<1.4 cm（P<0.05）;the incidence of mild varies in 49 patients with splenic vein diameter≥1.0 cm was 20.4%,much lower than 51.6% in 31 patients with splenic vein diameter <1.0 cm（P<0.05）,and the incidence of severe varies in patients with splenic vein diameter ≥1.0 cm was 51.0%,much higher than 22.6% in patients with splenic vein diameter<1.0 cm（P<0.05）. Conclusion Ultrasound has high sensitivity and specificity in diagnosis of patients with liver cirrhosis and portal hypertension,which might provide a hint for the degree of esophageal-gastric varices and guide the options for clinical diagnosis and treatment.

Key words: Cirrhosis, Doppler ultras onography, Portal hypertension, Endoscopy