Abstract: Objective To observe the clinical efficacy of octreotide and a herbal medicine compounds in the treatment of patients with liver cirrhosis complicated by upper gastrointestinal bleeding. Methods 76 hospitalized patients with upper gastrointestinal bleeding between January 2012 and January 2015 in our department were divided into observation group and control group（n=38 each）. The 38 patients in control were treated by intravenous octreotide,and another 38 in observation were treated by Gexiazhuyutang,a herbal medicine compounds,at the base of treatment in control. The regimen lasted for 2 weeks in both groups. The endoscopy and ultrasound were operated for check-up of efficacy. Results The average hemostasis time in observation was （35.82±12.47） h,much shorter than （49.16±11.58） h in control （t=10.254,P=10.254<0.05）;the TCM score at the end of treatment was （10.25±7.54）,much lower than （13.47±6.73） in control （t=4.538,P=0.000<0.005）;the portal vain blood flow was （580.34±176.38） ml/min,much lower than （650.25±142.47） ml/min in the control group （P<0.05）;Splenic venous blood flow （213.36±90.74） ml/min,much lower than （286.74±101.25） ml/min in the control （P<0.05）;Portal and splenic vein diameters reduced in both groups,but the improvement was obvious in observation group（P<0.05）. Conclusion The application of octreotide and a herbal medicine compounds in the treatment of patients with liver cirrhosis complicated by upper gastrointestinal bleeding is efficient and feasible with the portal vein hemodynamic improvement.

Key words: Liver cirrhosis, Gastrointestinal bleeding, Herbal medicine compounds, hemodynamic