Abstract: Objective The aims of this study was to investigate the prevalence and risk factors of non-alcoholic fatty liver disease（NAFLD）in checked-up subjects in Guangdong Province. Methods 20047 subjects were checked-up by ultrasound and blood parameters. Results The prevalence of NAFLD in this subjects was 13.2%,in which the prevalence of NAFLD in male subjects was significantly higher than that in the female subjects（18.8% vs 7.8%,P<0.01）;the peak prevalence（23.8% to 25.6%） occurred in persons of 50- to 69-year old age,which were obviously higher than those in the other groups（4.7% in younger than 30,10.8% in younger than 40,17.6% in younger than 50 and 18.7% in older than 79 years of age,P<0.01）;Individuals with hypertension,hyperlipidemia and hyperglycemia had higher prevalence of NAFLD than those without（31.3% vs. 10.0%,41.3% vs. 8.2%,and 27.9% vs. 10.6%,P<0.01）. Conclusions The prevalence of NAFLD is high in Guangdong Province and there is a closed correlation of NAFLD to hypertension,hyperlipidemia and hyperglycemia.

Key words: Non-alcoholic fatty liver disease, Prevalence, Hypertension, Hyperlipidemia, Individuals