Abstract: Objective To investigate the role of transjugular intrahepatic portosystemic shunt（TIPS） in the treatment of cirrhotics with portal hypertension. Methods A retrospective analysis was made on 147 patients with liver cirrhosis and portal hypertension,and all the patients received TIPS between March 2012 and January 2017. The patients received hepatic CT check-up and three-dimensional reconstruction of hepatic vein and portal vein was made. Results All the 147 patients were treated with TIPS by the right jugular vein approach,and 146 cases（99.3%） were successfully operated. Intraoperative punctures in bile duct,gallbladder,hepatic artery and liver capsule were 5 cases （3.4%）,2 cases （1.4%）,4 cases （2.7%） and 8 cases （5.5%）,whereas no abdominal or bile duct bleeding occurred;ectopic embolism occurred in 2 cases （1.4%）;the preoperative dry weight was （13.0±2.1） kg, fasting blood glucose was （6.4±1.0） mmol/L,fasting insulin levels was （20.2±9.3） mU/L,albumin was （37.4±5.0） g/L,creatinine was （59.2±15.9） μmol/L,urea was （5.1±1.6） mmol/L,total bilirubin was （18.6±5.0） μmol/L,blood ammonia was（66.8±24.3） μmol/L,while at the end of 3 months after TIPS,these indexes were （15.4±3.2） kg,（5.8±1.4） mmol/L,（15.3±3.3） mU/L,（34.8±3.6） g/L,（58.5±10.9） μmol/L,（4.1±1.6） mmol/L,（27.3±7.2） μmol/L and（70.1±34.4） μmol/L,respectively,suggesting postoperative portal venous pressure significantly decreased,dry weight and total bilirubin levels significantly increased; within 12 months of follow-up,there were stent stenosis in 31 cases （21.2%） and hepatic encephalopathy in 25 cases （17.12%）. Conclusion TIPS is a reliable method for treatment of liver cirrhosis with portal hypertension,which might effectively improve the patients' conditions. The key of the operation is the precise puncture,preoperative CT three-dimensional reconstruction of liver and hepatic vein and portal vein,and intraoperative portal vein angiography.

Key words: Cirrhosis, Portal hypertension, Transjugular intrahepatic portosystemic shunt, Therapy