Abstract: Objective To investigate the clinical significance of serum bilirubin and thyroid hormone levels in patients with diabetes mellitus type 2（T2DM）. Methods Blood from 87 patients with T2DM and 45 normal persons were tested the level of serum bilirubin and thyroid hormones. Results The FT3 and IBIL levels in T2DM were 2.6±1.1pmol/L and 5.0±2. 8μmol/L，and in normal control group were 4.8±1.0pmol/L and 8.8±2.6μmol/L，respectively;the FT3 levels in the poor glycemic control group，bad glycemic control group and normal control group were 3.88±0.67 pmol/L，3.16±0.84 pmol/L and 4.38±0.51pmol/L，and the IBIL levels were 7.25±4.38μmol/L，5.93±2.97μmol/L and 8.56±3.32μmol/L，respectively；The serum IBIL and FT3 levels in mild diabetes groups were 3.03±1.21pmol/L and 7.51±3.17μmol/L，in severe groups were 1.91±0.86pmol/L and 6.25±2.85μmol/L；the serum IBIL and FT3 levels in severe groups after treatment were 3.55±1.29pmol/L and 8.11±3.06μmol/L. Conclusion The changes of FT3 and IBIL levels are closely related to the progress and curative effect in T2DM.

Key words: Diabetes mellitus type 2, Bilirubin, Thyroid hormones