Abstract: Objective To investigate the clinical efficacy of plasma exchange in treatment of patients with hepatitis E and hyperbilirubinemia. Methods 61 patients with hepatitis E and hyperbilirubinemia were recruited in this study between February 2011 and May 2016,and the patients were divided into two group,with 32 cases receiving conventional treatment and 29 cases receiving plasma exchange （PE） at the base of conventional therapy. The clinical symptoms and serum parameters were measured. Results At the end of four week treatment,the total efficient rate in the PE-treated group was 96.6%,much higher than 62.5% （P<0.05） in the control;serum bilirubin,alanine aminotrasferase and gamma glutamyl transferas levels in the PE group were（73.4±52.）μmol/L,（75.9±58.4） U/L and（48.6±19.0） U/L,much lower than in the control【（166.3±81.2.） μmol/L,（147.8±47.0） U/L and（150.8±68.5） U/L,respectively,P<0.05】;serum renal function tests in the two groups were not significantly changed;all patients completed the PE procedure and survived without death,while three patients in the control died;the side effect including 9 allergic reaction and one hypotension occurred during PE,and all disappeared with appropriate management. Conclusions PE can remarkably decrease blood bilirumin levels and improve clinical symptoms,which might give the chance for further intervention for patients with hepatitis E and hyperbilirubinemia.

Key words: Hepatitis E, Hyperbilirubinemia, Plasma exchange, Efficacy