Abstract: Objective To investigate serum thyroid hormones,anti-thyroid autoantibodies and interleukin （IL）-6 levels and its clinical significance in patients with chronic hepatitis B virus（HBV） infection. Methods Eighteen healthy persons,65 patients with chronic hepatitis B（CHB）and 34 patients with hepatitis B liver cirrhosis were included in this study,and serum levels of thyroid hormones,anti-thyroid autoantibodies and IL-6 were determined by electrochemiluminescence. Results The serum levels of anti-thyroid peroxidase antibody（TPOAb）,anti-thyroglobulin antibody（TGAb）,anti-thyroid stimulating hormone receptor antibody（TRAb）and IL-6 in patients with CHB were（9.5±5.6） KIU/L,（42.5±218.7） KIU/L,（1.5±0.7） IU/L,and（6.6±12.6） pg/mL,respectively,and in cirrhotic patients were（9.5±8.6） KIU/L,（47.6±101.5） KIU/L,（2.2±1.7） IU/L and（15.8±25.5） pg/mL,respectively,all of which were significantly higher than those in normal controls[（4.4±5.6） KIU/L,（7.7±18.3） KIU/L,（0.8±0.8） IU/L and （2.8±2.0）pg/mL,respectively,P<0.05],while FT3 in patients with CHB and cirrhotics were （2.4±0.5） ng/L and（2.4±0.6）ng/L,respectively,significantly lower than that in normal controls[（2.9±0.2） ng/L,P<0.05];Serum TRAb and IL-6 levels in cirrhotic group were（2.2±1.7）IU/L and（15.8±25.5） pg/mL,respectively,significantly higher than that in patients with CHB[（1.5±0.7） IU/L and（6.6±12.6） pg/mL,respectively,P<0.05],while serum TT3 and TT4 levels in cirrhotic group were（0.8±0.3）nmol/L and（5.4±1.9） nmol/L,respectively,significantly lower than those in CHB group [（1.3±0.3） nmol/L and（8.0±2.2） nmol/L,respectively,P<0.05]. Conclusion Detection of serum thyroid hormones,anti-thyroid autoantibodies and IL-6 in patients with chronic HBV infection is of clinical significance in evaluation of the disease progress and prognosis.

Key words: Chronic hepatitis B, Liver cirrhosis, Thyroid hormones, Anti-thyroid autoantibodies, Interleukin 6