Abstract: Objective To explore the risk factor of nosocomial infection in patients with severe hepatitis. Methods 196 patients with severe hepatitis were analyzed retrospectively. Results The nosocomial infection rate in 196 patients was 50%（98/196）,out of which were spontanious bacterial peritonitis（88.8%）,biliary tract infection （42.9%）,intestinal infection（21.4%）,respiratory infection（12.2%） and others（9.2%）. The infection was related to the hospitalization,interventional treatment,hypoalbuminemia,administration of steroid and multiple infection. Conclusion Infection is important factor influencing the prognosis of patients with severe hepatitis.

Key words: Severe hepatitis, Nosocomial infection, Risk factor