关键词: 肝硬化, 自体外周血干细胞移植, 治疗

Abstract: Objective Currently,an available options for treatment of decompensated hepatitis B-induced liver cirrhosis are limited. Recently,stem cell transplantation has emerged as a promising alternative in this setting. The aim of this study was to evaluate the efficacy and safety of autologous peripheral blood stem cell transplantation （APBSCT） in patients with hepatitis B cirrhosis. Methods A total of 100 patients with hepatitis B-induced liver cirrhosis（LC） were devided into transplantation and control group,and 50 patients in control group were treated with conventional therapies,and other 50 patients in transplantation group were mobilized by injection of recombinant human granulocyte colony stimulating factor （rhG-CGF）,the peripheral blood stem cells were separated and collected and then the stem cells were injected directly into the proper hepatic artery. A six-month follow-up survey was conducted in all the patients. Results One month after the APBSCT,the main indexes of liver functions in the transplantation group improved as compared with those before operation,and serum bilirubin levels in transplantation group and control group were （34.5±17.2） μmol/L and （59.3±12.8） μmol/L,respectively,significantly different （P<0.05）,and serum albumin levels were （35.3±3.2） g/L and （30.2±1.5） g/L,significantly different （P<0.05）;at the end of six month transplantation,serum albumin levels were（30.6±4.4） g/L and （27.6±1.9）g/L,and Child-Pugh scores were （8.4±2.1） and （9.7±3.3）,respectively,significantly different （P<0.05）. Conclusion s Autologous peripheral blood stem cells transplantation for patients with LC is a safe and feasible procedure,which might improve the liver functions and life quality at short-term observation.

Key words: Liver cirrhosis, Autologous peripheral blood stem cells, Transplantation, Efficacy