关键词: 肝硬化, 胰岛素抵抗, 颈动脉硬化, 左心室功能, 评估

Abstract: Objective To investigate the changes of insulin resistance（IR）,carotid atherosclerosis and left ventricular function in patients with non-alcoholic fatty liver disease（NAFLD）-induced liver cirrhosis （LC）. Methods The clinical data of 64 patients with NAFLD-induced LC were retrospectively analyzed between June 2016 and June 2018. Out of them,26 were with Child-Pugh class A,21 with class B and 17 were with class C. 30 healthy volunteers were recruited serving as control. The IR-related indicators,such as fasting blood glucose （FPG）,fasting insulin （FINS） and insulin sensitivity index（ISI）],as well as carotid intima-media thickness （IMT） and left ventricular Tei index were obtained. Results In the patients with Child class A,B ad C,the FPG levels were （5.5±1.1） mmol/L,（5.6±1.2） mmol/L and （5.8±1.4） mmol/L,respectively,all significantly higher than [（4.8±0.8） mmol/L,P<0.05] in the control;FINS levels were（8.7±1.7） mIU/L,（10.9±2.2） mIU/L and（15.1±3.1） mIU/L, respectively,all significantly higher than [（6.5±1.3） mIU/L,P<0.05] in the control;ISI were （-4.5±0.4）,（-4.8±0.5） and（-5.1±0.7）,respectively,all significantly lower than[（-4.0±0.3）,P<0.05] in the control;the carotid IMT in patients with Child A,B and C were （0.8±0.1） mm,（1.1±0.2） mm and （1.3±0.3） mm,respectively,all significantly greater than [（0.5±0.1） mm,P<0.05] in the control;carotid PWVES were （8.1±1.3） m/s,（8.5±1.6） m/s and （8.7±1.8）m/s,all significantly higher than [（7.4±1.1） m/s,P<0.05] in the control;left ventricular Tei index were （0.38±0.08）,（0.44±0.09） and（0.52±0.12）,respectively,all significantly higher than [（0.32±0.05）,P<0.05] in the control. Conclusion Patients with NAFLD-induced LC have IR,as well as carotid atherosclerosis and left ventricular dysfunction,which might have a common pathogenesis and needs early intervention.

Key words: Liver cirrhosis, Insulin resistance, Carotid atherosclerosis, Left ventricular function, Evaluation