基于Exchange血流动力学模型的MRI扫描参数诊断肝硬化临床价值分析*

doi:10.3969/j.issn.1672-5069.2019.05.021

实用肝脏病杂志 ›› 2019, Vol. 22 ›› Issue (5): 696-699.doi: 10.3969/j.issn.1672-5069.2019.05.021

基于Exchange血流动力学模型的MRI扫描参数诊断肝硬化临床价值分析*

黄汉军, 鲁凤荣, 张灿

430012 武汉市华中科技大学同济医学院附属武汉精神卫生中心放射科（黄汉军, 鲁凤荣）; 附属协和医院放射科（张灿）

收稿日期:2019-01-08 出版日期:2019-09-10 发布日期:2019-09-16
通讯作者: 张灿,E-mail：149736813@qq.com
作者简介:黄汉军,男,47岁,大学本科,主治医师。研究方向：医学影像学诊断研究。E-mail：117220993@qq.com
基金资助:
武汉市医药卫生科技发展计划项目（编号：2089188）

Clinical value of MRI scanning based on exchange hemodynamics model in evaluating liver cirrhosis

Huang Hanjun, Lu Fengrong, Zhang Can

Department of Radiology,Mental Health Center,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430012,Hubei Province,China

Received:2019-01-08 Online:2019-09-10 Published:2019-09-16

摘要/Abstract

摘要： 目的探讨MRI增强扫描Exchange血流动力学模型评估肝硬化患者病情的临床应用价值及其意义。方法在60例慢性乙型肝炎和慢性丙型肝炎患者及30例健康体检者,均接受肝活检和肝脏DCE-MRI检查,通过检测双输入双室Exchange血流动力学模型得到参数指标,包括对比剂容积转运常数（Ktrans）、速度常数（Kep）、血管外细胞外间隙容积分数（Ve）、血浆容积分数（Vp）、肝动脉灌注指数（HPI）以及对比剂平均通过时间（MTT）、达峰时间（TTP）、血容量（BV）、血流量（BF）。结果在60例患者中,经肝组织病理学检查,诊断为S1期3例,S2期3例,S3期1例和S4期53例;肝纤维化患者Ktrans和Ve指标较对照组显著降低（P<0.05）,而HPI、MTT、TTP水平较对照组显著升高（P<0.05）;ROC曲线分析显示Ktrans、HPI、MTT和TTP诊断肝硬化的效能较高（P<0.05）。结论基于双输入双室Exchange血流动力学模型的DCE-MRI检查可得到多个定量参数,在诊断肝硬化方面具有良好的指导意义。

关键词: 肝硬化, 磁共振扫描, Exchange模型, 诊断

Abstract: Objective To investigate the clinical value of MRI enhanced exchange hemodynamic model in evaluating liver cirrhosis. Methods

Results Out of 60 patients with chronic hepatitis B and chronic hepatitis C,the histopathological examination showed that fibrosis S1 in 3,S2 in 3,S3 in 1 and S4 in 53;the Ktrans and Ve in patients with advanced fibrosis decreased,while HPI,MTT and TTP increased significantly as compared to those without （P<0.05）;ROC analysis showed that Ktrans,HPI,MTT and TTP had a high efficacy in diagnosing liver cirrhosis（P<0.05）. Conclusion Several quantitative parameters can be obtained in DCE-MRI based on double-input and double chamber exchange hemodynamics model,which might be good parameters in guiding the diagnosis of patients with liver cirrhosis.

Key words: Liver cirrhosis, Magnetic resonance imaging, Exchange model, Diagnosis

黄汉军, 鲁凤荣, 张灿. 基于Exchange血流动力学模型的MRI扫描参数诊断肝硬化临床价值分析*[J]. 实用肝脏病杂志, 2019, 22(5): 696-699.

Huang Hanjun, Lu Fengrong, Zhang Can. Clinical value of MRI scanning based on exchange hemodynamics model in evaluating liver cirrhosis[J]. Journal of Practical Hepatology, 2019, 22(5): 696-699.

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基于Exchange血流动力学模型的MRI扫描参数诊断肝硬化临床价值分析*

Clinical value of MRI scanning based on exchange hemodynamics model in evaluating liver cirrhosis

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