关键词: 微小病毒B19, 病毒性肝炎, 临床特征

Abstract: Objective To observe the clinical manifestation,laboratory examinations and therapy of patients with human parvovirus B19 infection. Methods 19 hospitalized patients in our hospital from August,2008 to July,2010 infected with human parvovirus B19 were investigated by clinical presentation,laboratory examinations and related therapy. Results The 19 hospitalized patients infected with human parvovirus B19 mainly presented symptoms with fatigue （12 cases）,jaundice （10 cases）,splenomegaly（10 cases）,fever （10 cases）,rash （6 cases）,myalgia and arthralgia（6 cases）. Six patients out of the 19 patients had following diseases or complications,such as pregnancy（1 case）,acute liver failure（2 cases）,schizophrenia（1 case）,acute myelosuppression（1 case） and pneumonia （1 case）. The characteristics of liver dysfunction showed elevated liver enzymes（AST/ALT）,mild or moderate jaundice,decreased PTA and normal CHE. The laboratory examinations in the 19 hospitalized patients with human parvovirus B19 infection were got back to normal and they all recovered after active symptomatic treatment （protecting liver function,decreasing liver enzymes,decreasing jaundice and administration of prednisolone and gamma globulin in some patients）. Conclusion Human parvovirus B19 is the only agent resulting in human diseases in Genus Parvovirus. The human parvovirus B19 can cause a series of clinical diseases including erythema infectiosum,natural abortion,myelosuppression and arthritis,etc. This article demonstrates that human parvovirus B19 is correlated with human hepatitis. Human parvovirus B19 might be an important pathogen for non hepatitis A to E. Human parvovirus B19 can results in hepatic lesion and cause acute hepatitis or acute fulminant hepatitis. It seemed that the hepatic lesion caused by human parvovirus B19 is an acute/subacute benign process and is prone to natural self-recovery.

Key words: Human parvovirus B19, Viral hepatitis, Clinical feature