二肽基肽酶-4在慢性肝病发病中的作用研究进展

doi:10.3969/j.issn.1672-5069.2016.05.035

摘要/Abstract

摘要： 二肽基肽酶-4（DPP-4）是膜相关酶,又称T细胞表面抗原CD26,在体内广泛分布,作用广泛。最有代表的作用靶肽是胰高血糖素样肽（GLP）-1,而GLP-1的失活导致糖耐量减低和糖尿病。除了其肽酶作用之外,DPP-4与免疫激活密切相关,结合并降解细胞外基质,对抗抗癌剂以及脂质积累。最近的研究表明,肝脏表达高水平的DPP-4,DPP-4在各种慢性肝病（如丙型肝炎病毒感染、非酒精性脂肪性肝病和肝细胞癌）的发病中有一定的作用。此外,在肝脏,干细胞也表达DPP-4,提示其在肝移植中有重要作用。本文介绍了DPP-4的分布及生物活性,重点讨论了DPP-4在慢性肝病发病中的作用以及DPP-4抑制剂的临床应用前景。

关键词: 病毒性肝炎, 非酒精性脂肪性肝病, 二肽基肽酶-4, 肠促胰素, 胰岛素抵抗

Abstract: Dipeptidyl peptidase-4（DPP-4） is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and has pleiotropic effects. A representative target peptide is glucagon-like peptide-1 （GLP-1）,and inactivation of GLP-1 results in the development of glucose intolerance/diabetes mellitus. In addition to its peptidase activity,DPP-4 is associated with immune stimulation, binding to and degradation of extracellular matrix,resistance to anti-cancer agents,and lipid accumulation. The liver expresses DPP-4 to a higher degree,and recent studies suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection,non-alcoholic fatty liver disease,and hepatocellular carcinoma. Furthermore,hepatic stem cells express DPP-4,which might plays a crucial role in hepatic regeneration. In this paper,we reviewed the tissue distribution and various biological effects of DPP-4. The impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor were also discussed.

Key words: Viral hepatitis, Non-alcoholic fatty liver disease, Dipeptidyl peptidase-4, Incretin, Insulin resistance

张婷婷综述, 王煊审校. 二肽基肽酶-4在慢性肝病发病中的作用研究进展[J]. 实用肝脏病杂志, 2016, 19(5): 637-640.

Zhang Tingting, Wang Xuan.. What roles does dipeptidyl peptidase-4 play in chronic liver diseases?[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(5): 637-640.

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