关键词: 药物性肝损伤, 肝衰竭, 临床特征, 回顾性分析

Abstract: Objective To explore the related drugs,clinical characteristics and prognosis of patients with drug-induced liver failure （DILF）. Method A total of 314 patients with DILF were collected between March 2002 and March 2015 in our hospital. According to Roussel Uclaf causality assessment method score,the underlying diseases,induced drugs,clinical characteristics,treatment and prognosis were retrospectively analyzed. Result Out of the 314 patients with DILF,there were 97 men and 217 women with the proportion of male to female being 1:2.5,and the average age was（43.8±17.0） yr;there was a statistically significant difference between male and female patients at age of 30 to 39 yr;the proportion of DILF accounting for liver failure was on the rise in our hospital in recent decade;the main induced drugs were traditional Chinese herbal medicine（45.5%）,antipyretic analgesics（18.0%）,antituberculosis medicine（12.6%）,etc;the underlying diseases were mainly fever（20.1%）,dermatosis（15.6%） and tuberculosis （12.7%）,etc;the clinical catalogue was mainly subacute liver failure （60.9%）,and the main clinical type was hepatocyte damage（56.7%）;at the end of three month observation,the survival rate was 58.9%. Conclusion In recent decade,the incidence of DILF in our hospital has been increasing rapidly with variety of causative medicine and high mortality,which warrants further study.

Key words: Drug induced liver injury, Liver failure, Clinical feature, Retrospective analysis