Abstract: Objective To investigate the clinical effects of transcatheter arterial chemoembolization （TACE） combined with three dimensional conformal radiotherapy（3-DCRT）on patients with advanced hepatocellular carcinoma.Methods A total of 87 patients with advanced hepatocellular carcinoma were randomly divided into TACE/3-DCRT group（n=45）and TACE group （n=42）.The patients in TACE/3-DCRT group were treated first with TACE and then 3-DCRT，the dose was 2.6～3.2Gy each time， and the total dose was 48～60Gy. The patients in TACE group were given TACE only.Results The total response （CR+PR） were 86.7% in TACE/3-DCRT group， much higher than 66.7% in TACE group（P<0.05）;The 1，2，3-year survival rates were 73.3%，53.3%，35.6% and 59.5%，31.0%，14.3%，respectively in the two groups.Conclusions TACE combined with 3-DCRT is more effective than TACE only，and the side effects are tolerated.

Key words: Hepatoma, Three dimensional conformal radiotherapy, Transcatheter arterial chemoembolization