Abstract: Objective To explore the effect and safety of autologous bone marrow stem cell transplantation via hepatic artery in treatment of patients with decompensated cirrhosis.Methods 425 patients with decompensated liver cirrhosis were selected for the trail.Beside the conventional treatment，the bone marrow stem cells were transplanted into the liver via hepatic artery.The biochemical index of liver function，abdominal B ultrasound and liver CT were detected at different times after transplantation.Results There was no severe side effects in all the 425 patients after the operation. 2 weeks after transplantation，abdominal distention was alleviated in 213 patients，8 weeks after transplantation，appetite was improved in 297 patients.12 weeks after transplantation，ALB increased from 26.6±5.2g/L to 37.5±4.9g/L（P<0.05），ALT decreased from 150.7±19.5U/L to 30.7±7.7U/L（P<0.05）， AST decreased from 85.6±32.5U/L to 20.5±15.7 U/L（P<0.05），TBIL decreased from 154.4±20.2μmol/L to 52.3±17.4μmol/L，PT decreased from 20.1±1.7s to 15.4±1.5s. Conclusion Transplantation of autologous bone marrow stem cells via hepatic artery is safe and effective in the treatment of patients with decompensated cirrhosis.

Key words: Cirrhosis, Autologous bone marrow stem cells, Transplantation, Hepatic artery