补体C5基因多态性与肝硬化发病的关系研究

doi:10.3969/j.issn.1672-5069.2011.06.011

Abstract

Abstract: Objective To evaluate the relationship of polymorphism of complement C5 gene and occurrence of liver cirrhosis in patients with chronic hepatitis B.Methods Polymorphism of complement C5 gene rs17611 was examined in 182 Chinese patients with chronic hepatitis B or liver cirrhosis by using TaqMan PCR genotyping method.Results Patients with genotypes G/G，A/G and A/A were detected with A/A genotype higher in patients with liver cirrhosis（P=0.022）;By multivariate logistic regression analysis，genotype A/A was an independent factor associated with liver cirrhosis （odds ratio=5.1，P=0.008）.Conclusion Polymorphism of complement C5 gene rs17611 is associated with progression of liver disease in Chinese patients with hepatitis B virus infection.

Key words: Hepatitis B, Liver cirrhosis, Complement C5, Polymorphism

LI Changzheng，Guo Shuilong，LI Qingshan，et al.. Polymorphism of complement C5 gene and susceptibility to liver cirrhosis in patients with chronic hepatitis B[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(6): 427-429.

References

[1] MUHLBAUER M，BOSSERHOFF AK，HARTMANN A，et al.A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease[J]. Gastroenterology，2003，125:1085-1093.
[2] KNAPP S，HENNIG BJ，FRODSHAM AJ，et al.Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection[J]. Immunogenetics，2003，55:362-369.
[3] GOYAL A，KAZIM SN，SAKHUJA P，et al.Association of TNF-beta polymorphism with disease severity among patients infected with hepatitis C virus[J]. J Med Virol，2004，72:60-65.
[4] WRIGHT M，GOLDIN R，HELLIER S，et al.Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection[J]. Gut，2003，52:1206-1210.
[5] LI CZ，KATO N，CHANG JH，et al.Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication[J]. Liver Int，2009，29（9）:1413-1421.
[6] HILLEBRAND S，WASMUTH HE，WEISKIRCHEN R，et al.Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans[J]. Nat Genet，2005，37:835-843.
[7] ADDIS-LIESER E，KOHL J，CHIARAMONTE MG.Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis[J]. J Immunol，2005，175（3）:1894-1902.
[8] BOOR P，KONIECZNY A，VILLA L，et al.Complement C5 mediates experimental tubulointerstitial fibrosis[J]. J Am Soc Nephrol，2007，18（5）:1508-1515.
[9] SCHLAF G，SCHMITZ M，ROTHERMEL E，et al.Expression and induction of anaphylatoxin C5a receptors in the rat liver[J]. Histol Histopathol，2003，18（1）:299-308.
[10] DMYTRIJUK A，ROBIE-SUH K，COHEN MH，et al.FDA report: eculizumab （Soliris） for the treatment of patients with paroxysmal nocturnal hemoglobinuria[J]. Oncologist，2008，13（9）:993-1000.

[1]	Zhuang Ying, Lin Zhihui.. Clinical manifestations and diagnosis of portal vein thrombosis [J]. Journal of Practical Hepatology, 2019, 22(6): 765-767.
[2]	chronic hepatitis B Zhu Lingyun, Zhang Maohai Cui Shasha, et al.. Serum IL-12 and IL-18 levels as well as peripheral blood mononuclear cell FOXp3 in patients with [J]. Journal of Practical Hepatology, 2019, 22(6): 816-819.
[3]	Shi Yingying, Wang Yuanxi.. Impact of combination telbivudine and adefovir dipivoxil on renal functions in the treatment of patients with chronic hepatitis B [J]. Journal of Practical Hepatology, 2019, 22(6): 820-823.
[4]	Min Feng, Huang Wenqi, Wu Weibing, et al.. Implications of serum adipocytokine levels in patients with chronic hepatitis B [J]. Journal of Practical Hepatology, 2019, 22(6): 824-827.
[5]	patients with chronic hepatitis B Zhang Yingming, Shen Shuang, Tian Fei, et al.. Prediction of response to peginterferon alfa-2a by blood IFNL4 and IL-28B gene polymorphisms in [J]. Journal of Practical Hepatology, 2019, 22(6): 828-831.
[6]	chronic hepatitis B virus carriers Wu Haiyi, Chen Jianxin.. Diagnostic efficacy of four non-invasive diagnostic models in evaluating significant liver fibrosis in [J]. Journal of Practical Hepatology, 2019, 22(6): 832-835.
[7]	Ma Liying, Shen Lijuan.. Efficacy and safety of tenofovir in the treatment of pregnant women with high HBV DNA loads [J]. Journal of Practical Hepatology, 2019, 22(6): 836-839.
[8]	Li Yingyi, Guo Cuifen, Zhang Ruinan, et al.. Correlation of polymorphism of ALDH2 rs671 to morbidity in individuals prone to nonalcoholic fatty liver disease [J]. Journal of Practical Hepatology, 2019, 22(6): 848-851.
[9]	Yang Caiyong, Chen Na, Li Kui, et al.. Clinical significance of peripheral blood Treg and Th17 cells in patients with chronic hepatitis C and hepatitis C-induced liver cirrhosis [J]. Journal of Practical Hepatology, 2019, 22(6): 868-871.
[10]	Wu Dan Ma Xiangying.. Insulin resistance,carotid atherosclerosis and left ventricular function in patients with NAFLD-induced liver cirrhosis [J]. Journal of Practical Hepatology, 2019, 22(6): 876-879.
[11]	He Zhi’an, Yu Liping, Lai Jiangqiong, et al.. Evaluation of varices bleeding and portal vein thrombosis by ARFI in patients with cirrhosis and esophagogastric varices [J]. Journal of Practical Hepatology, 2019, 22(6): 888-891.
[12]	Li Chuanjie, Xu Jing, Wang Liangliang, et al.. Changes of serum HBsAg levels in patients with chronic hepatitis B receiving entecavir treatment [J]. Journal of Practical Hepatology, 2019, 22(6): 928-929.
[13]	Du Keye, Yang Dongliang, Liu Jia. Regulatory T cells in hepatitis B [J]. Journal of Practical Hepatology, 2019, 22(5): 613-616.
[14]	Liao Guichan, Peng Jie, Zhang Xiaoyong. Roles of hepatocytes in intrinsic innate immunity in control of hepatits B virus infection [J]. Journal of Practical Hepatology, 2019, 22(5): 617-619.
[15]	Zhao Xieshan, Wu Chunrong, Wang Chunfeng, et al. Preliminary study on the efficacy of combination of tenofovir and Anluo Huaxian pill in the treatment of patients with HBeAg-negative chronic hepatitis B [J]. Journal of Practical Hepatology, 2019, 22(5): 644-647.

Polymorphism of complement C5 gene and susceptibility to liver cirrhosis in patients with chronic hepatitis B

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments