超声引导下PTGD联合聚桂醇硬化治疗单纯性肝囊肿患者疗效研究*

doi:10.3969/j.issn.1672-5069.2024.03.034

Abstract

Abstract: Objective The aim of this study was to investigate the efficacy of percutaneous transhepatic gallbladder drainage (PTGD) and lauromacrogol sclerotherapy under ultrasound(US) guidance in patients with simple hepatic cysts (SHC). Methods 67 patients with SHC were enrolled in our hospital between June 2021 and August 2022, and were divided randomly into observation (n=34) and control group (n=33). All patients received US-guided PTGD, while the patients in the control group were given anhydrous ethanol for sclerotherapy, and those in the observation group were given lauromacrogol for sclerotherapy. The patients in both groups were followed-for 6 months after treatment. Serum cortisol (Cor) level was detected by ELISA, and serum amyloid A (SAA) and C-reactive protein (CRP) levels were detected by chemiluminescence assay. Results At the end of 6 months after treatment, the total effectiveness rates between the two groups were not statistically significantly different (97.1% vs. 93.9%, P>0.05); at month 1, 3 and 6 after treatment, the reduction rates of cyst volumes in the observation group was (69.1±7.3) %, (84.6±6.9) % and (92.8±3.7) %, significantly greater than those in control group [(56.8±6.4) %, (75.3±5.7) % and (86.3±4.9) %, P<0.05]; there were no significant differences as respect to serum liver biochemical parameters before and one week after the treatment between the two groups(P＞0.05; at the end of one week after treatment, serum Cor and SAA levels in the observation group were (260.4±15.6)nmol/L and (13.9±2.1)mg/L, both significantly lower than [(305.8±18.9)nmol/L and (18.6±2.7)mg/L, respectively, P＜0.05] in the control; the incidence of untoward effects in the observation group was 5.8%, much lower than 24.2%(P＜0.05) in the control group. Conclusion The efficacy of US-guided PTGD and lauromacrogol sclerotherapy is definitely satisfactory in dealing with patients with SHC, which could effectively reduce the cyst volumes, relieve body stress response and reduce adverse reactions.

Key words: Simple hepatic cyst, Ultrasound guidance, Lauromacrogol, Percutaneous transhepatic gallbladder drainage, Sclerotherapy

Wang Lingru, Su Hong, Hao Xiaowei, et al. Disappearance of simple hepatic cysts after percutaneous transhepatic gallbladder drainage and lauromacrogol sclerotherapy under ultrasound guidance: A single center observation[J]. Journal of Practical Hepatology, 2024, 27(3): 454-457.

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Disappearance of simple hepatic cysts after percutaneous transhepatic gallbladder drainage and lauromacrogol sclerotherapy under ultrasound guidance: A single center observation

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