Abstract: Objective The aim of this study was to investigate the efficacy of ultrasound-guided percutaneous catheter aspiration and sclerotherapy with polygui alcohol foam in the treatment of patients with simple hepatic cyst (SHC). Methods 112 patients with SHC were randomly divided into observation group (n=56) and control group (n=56), and the patients in the observation group were treated with ultrasound-guided percutaneous catheter drainage with polygui alcohol foam sclerosis and those in the control group were treated with ultrasound-guided percutaneous catheter drainage with 1% lauromacrogol sclerotherapy. All patients were followed-up for six months. Serum C-reactive protein (CRP) level was detected by chemiluminescence method, serum cortisol (Cor) level was detected by magnetic particle chemiluminescence method, and blood glucose (GLU) level was detected by hexokinase method. Results Six months after operation, the total effective rate in the observation group was 100.0%, which was not statistically different compared to 92.9% in the control group (P>0.05); the incidence of adverse reactions in the observation group was 5.4%, which was significantly lower than 19.6% (P<0.05) in the control group; 1 week after treatment, serum bilirubin, alanine aminotransferase, aspartate aminotransferase, ALP, CHE, CRP, cortisol and blood glucose levels in the two groups were not significantly different (P>0.05). Conclusion Ultrasound-guided percutaneous puncture with catheter drainage and polygui alcohol foam sclerosis in treatment of patients with simple hepatic cysts is efficacious, which might decrease the side effects and is a safe procedure, warranting further clinical application.

Key words: Simple hepatic cyst, Ultrasound-guidance, Percutaneous puncture and catheter drainage, Polygui alcohol foam sclerosis, Treatment