Abstract: Objective The aim of this study was to investigate the efficacy and safety of ultrasound-guided percutaneous microwave ablation for the treatment of patients with hepatic alveolar echinococcosis. Methods 50 patients with early hepatic vesicular echinococcosis were treated in our hospital between June 2018 and October 2019, and they were divided randomly into control (n=25) and observation group (n=25). The patients in the control group were treated with conventional open surgery, and those in the observation group were treated with microwave ablation under ultrasound guidance. The followed-up period was 1 year. Results The total effective rate in the observation group was 92.0%, which was significantly higher than that in the control group [80.0%, P<0.05]; 1 week after operation, serum total bilirubin level in the observation group was (16.7±1.6) μmol/L, which was not significantly different as compared to that in the control group [(14.2±1.4) μmol/L, P<0.05], serum alanine aminotransferase level in the observation group was (140.8±52.4 ) U/L, which was significantly lower than [(194.7 ± 63.2) U/L, P<0.05]in the control group, and serum GGT level was (95.1±10.2) U/L, which was significantly lower than in the control group [(102.4±11.3) U/L, P<0.05], while serum albumin level in the observation group was (35.7±3.4) g/L, which was significantly higher than that in the control group [ (32.9±3.5) g/L, P<0.05]; the complication rate in the observation group during the follow-up period was 4.0%, significantly lower than36.0%(P＜0.05)in the control. Conclusion The ultrasound-guided microwave ablation in the treatment of patients with hepatic alveolar echinococcosis is efficacious, which might reduce the incidence of post-operational complications.

Key words: Hepatic alveolar echinococcosis, Ultrasound-guidance, Microwave ablation, Therapy